Tumor-infiltrating lymphocytes (TILs), frontline soldiers of the adaptive immune system, are
recruited into the tumor site to fight against tumors. However, their small number and …

The epithelial cell adhesion molecule (EpCAM) is a single transmembrane protein on the
cell surface. Given its strong expression on epithelial cells and epithelial cell-derived tumors …

Lenvatinib (LVN) has been appoved to treat advanced renal cell carcinoma, differentiated
thyroid carcinoma, hepatocellular carcinoma. Further other cancer types also have been …

Non-alcoholic fatty liver disease (NAFLD) is a global health problem characterized by
altered lipid and redox homeostasis, mitochondrial dysfunction, and endoplasmic reticulum …

Background The nuclear factor kappa B (NF-κB) is a critical pathway that regulates various
cellular functions, including immune response, proliferation, growth, and apoptosis …

Introduction Small-cell lung cancer (SCLC) accounts for 15% of lung cancers and has a
dismal prognosis due to early dissemination and acquired chemoresistance. The initial good …

Researchers have tried to find novel strategies for cancer treatment in the past decades.
Among the utilized methods, administering oncolytic viruses (OVs) alone or combined with …

Protein-based cancer therapies are considered an alternative to conventional anticancer
regimens, providing multifunctional properties while showing low toxicity. However, its …

Abstract Ethnopharmacological relevance Litchi chinensis Sonn.(Litchi) seed, a traditional
Chinese medicine, is habitually used in the clinical treatment of prostate cancer (PCa) …

Most patients with metastatic colorectal cancer (mCRC) have limited treatment options
following standard-of-care therapy. VEGFR-tyrosine kinase inhibitors (TKIs) have …