Liver sinusoidal endothelial cells (LSECs) form the wall of the hepatic sinusoids. Unlike
other capillaries, they lack an organized basement membrane and have cytoplasm that is …

The complex functions of the liver in biosynthesis, metabolism, clearance, and host defense
are tightly dependent on an adequate microcirculation. To guarantee hepatic homeostasis …

Context Kaempferol, a flavonoid glycoside, has many hepatoprotective effects in several
animals due to its antioxidant potential. Objective This study evaluated the hepatoprotective …

Acute hepatic failure (AHF) is a severe liver injury accompanied by hepatic encephalopathy
which causes multiorgan failure with an extremely high mortality rate, even if intensive care …

Paracetamol (APAP) is one of the most widely used and popular over-the-counter analgesic
and antipyretic drugs in the world when used at therapeutic doses. APAP overdose can …

The liver is innervated by autonomic and sensory fibers of the sympathetic and
parasympathetic nervous systems that regulate liver function, regeneration, and disease …

Acetaminophen (APAP), a widely used antipyretic and analgesic drug in clinics, is relatively
safe at therapeutic doses; however, APAP overdose may lead to fatal acute liver injury …

BACKGROUND: Paracetamol overdose causes severe hepatotoxicity that leads to liver
failure in both humans and experimental animals. The present study investigates the …

Context: Overdose of acetaminophen (APAP) is common in humans and is often associated
with hepatic damage. Withania somnifera (L.) Dunal (Solanaceae) shows multiple …

Background Acute paracetamol (PCM) toxicity is a clinical problem; can result in a serious
liver injury that finally may progress to acute liver failure. Curcumin (CUR) is a prevalent …