It is widely accepted that alterations to cyclooxygenase-2 (COX-2) expression and the
abundance of its enzymatic product prostaglandin E 2 (PGE 2) have key roles in influencing …

Aging represents the multifactorial decline in physiological function of every living organism.
Over the past decades, several hallmarks of aging have been defined, including epigenetic …

Although DNA methylation is a key regulator of gene expression, the comprehensive
methylation landscape of metastatic cancer has never been defined. Through whole …

Abstract Knowledge of epigenetic alterations in disease is rapidly increasing owing to the
development of genome-wide techniques for their identification. The ever-growing number …

Sfanos KS & De Marzo AM (2012) Histopathology 60, 199–215 Prostate cancer and
inflammation: the evidence Chronic inflammation is now known to contribute to several …

Loss of androgen receptor (AR) signaling dependence occurs in approximately 15%–20%
of advanced treatment-resistant prostate cancers, and this may manifest clinically as …

In children, cancer probably arises from a combination of inherited genetic mutations and
genetic alterations that are acquired during the rapid cellular expansion that occurs during …

Many studies have shown that primary prostate cancers are multifocal,, and are composed
of multiple genetically distinct cancer cell clones,,. Whether or not multiclonal primary …

The emergence of nanotechnology applied to medicine has revolutionized the treatment of
human cancer. As in the case of classic drugs for the treatment of cancer, epigenetic drugs …

Cancer is characterized by hypomethylation-associated silencing of large chromatin
domains, whose contribution to tumorigenesis is uncertain. Through high-resolution genome …