Currently, enhancement of cholinergic neurotransmission via cholinesterase inhibitors
represents the main available approach to treat cognitive and behavioural symptoms of the …

Acetylcholine (ACh) has a crucial role in the peripheral and central nervous systems. The
enzyme choline acetyltransferase (ChAT) is responsible for synthesizing ACh from acetyl …

Alzheimer's disease (AD) constitutes the most prominent form of dementia among elderly
individuals worldwide. Disease modeling using murine transgenic mice was first initiated …

We identified axonal defects in mouse models of Alzheimer's disease that preceded known
disease-related pathology by more than a year; we observed similar axonal defects in the …

Estrogens play a crucial physiological function in the brain; however, debates exist
concerning the role of estrogens in Alzheimer's disease (AD). Women during pre-, peri-, or …

Alzheimer's disease (AD) is the most common form of degenerative dementia and is
characterized by progressive impairment in cognitive function during mid-to late-adult life …

The cholinergic hypothesis of cognitive impairment and Alzheimer's disease has been for
decades a “polar star” for studies on dementia and neurodegenerative diseases. Aim of the …

Alzheimer's disease (AD), the most common cause of dementia among the elderly, may
either represent the far end of a continuum that begins with age-related memory decline or a …

Alzheimer's disease is an age-related neurodegenerative disorder that is characterized by a
progressive loss of memory and deterioration of higher cognitive functions. The brain of an …

Animal models aim to replicate the symptoms, the lesions or the cause (s) of Alzheimer
disease. Numerous mouse transgenic lines have now succeeded in partially reproducing its …