Upon receipt in the dorsal horn (DH) of the spinal cord, nociceptive (pain-signalling)
information from the viscera, skin and other organs is subject to extensive processing by a …

Opioids mediate their effects via opioid receptors: mu, delta, and kappa. At the neuronal
level, opioid receptors are generally inhibitory, presynaptically reducing neurotransmitter …

Agonists for the μ-opioid receptor are powerful analgesics and are highly addictive;
however, the contribution of the δ-and κ-opioid and opioid receptor-like receptors to …

This paper is the 28th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning over a quarter-century of research. It …

Despite high sequence similarity between NOP (nociceptin/orphanin FQ opioid peptide) and
opioid receptors, marked differences in endogenous ligand selectivity, signal transduction …

Opioids targeting mu; μ (MOP) receptors produce analgesia in the peri-operative period and
palliative care. They also produce side effects including respiratory depression …

The opioid system may be involved in the pathogenesis of AD, including cognitive
impairment, hyperphosphorylated tau, Aβ production, and neuroinflammation. Opioid …

The advance of functional genomics revealed the superfamily of G-protein coupled
receptors (GPCRs). Hundreds of GPCRs have been cloned but many of them are orphan …

Opioid receptors are G protein-coupled receptors (GPCRs) that regulate activity within
peripheral, subcortical and cortical circuits involved in pain, reward, and aversion …

Opioids are involved in the physiological control of numerous functions of the central
nervous system, particularly nociception. It appears that some endogenous neuropeptides …