[HTML][HTML] The translational genetics of ADHD and related phenotypes in model organisms

J Cabana-Domínguez, E Antón-Galindo… - … & biobehavioral reviews, 2023 - Elsevier
Attention-deficit/hyperactivity disorder (ADHD) is a highly prevalent neurodevelopmental
disorder resulting from the interaction between genetic and environmental risk factors. It is …

[HTML][HTML] Alternative models for transgenerational epigenetic inheritance: Molecular psychiatry beyond mice and man

GR Hime, SLA Stonehouse, TY Pang - World journal of psychiatry, 2021 - ncbi.nlm.nih.gov
Mental illness remains the greatest chronic health burden globally with few in-roads having
been made despite significant advances in genomic knowledge in recent decades. The field …

The Use of Drosophila to Understand Psychostimulant Responses

TJ Philyaw, A Rothenfluh, I Titos - Biomedicines, 2022 - mdpi.com
The addictive properties of psychostimulants such as cocaine, amphetamine,
methamphetamine, and methylphenidate are based on their ability to increase …

Genotype and Trait Specific Responses to Rapamycin Intake in Drosophila melanogaster

PD Rohde, A Bøcker, CAB Jensen, AL Bergstrøm… - Insects, 2021 - mdpi.com
Simple Summary Rapamycin is commonly used as an immunosuppressant, but also as an
anti-aging medicine. Despite its widespread use, results suggest that there is large …

EasyFlyTracker: A Simple Video Tracking Python Package for Analyzing Adult Drosophila Locomotor and Sleep Activity to Facilitate Revealing the Effect of …

S Qu, Q Zhu, H Zhou, Y Gao, Y Wei, Y Ma… - Frontiers in Behavioral …, 2022 - frontiersin.org
The mechanism of psychiatric drugs (stimulant and non-stimulant) is still unclear. Precision
medication of psychiatric disorders faces challenges in pharmacogenetics and …

The effects of methylphenidate and atomoxetine on Drosophila brain at single-cell resolution and potential drug repurposing for ADHD treatment

S Qu, X Zhou, Z Wang, Y Wei, H Zhou, X Zhang… - Molecular …, 2024 - nature.com
The stimulant methylphenidate (MPH) and the non-stimulant atomoxetine (ATX) are
frequently used for the treatment of attention-deficit/hyperactivity disorder (ADHD); however …

Prediction of complex phenotypes using the Drosophila melanogaster metabolome

PD Rohde, TN Kristensen, P Sarup, J Muñoz… - Heredity, 2021 - nature.com
Understanding the genotype–phenotype map and how variation at different levels of
biological organization is associated are central topics in modern biology. Fast …

[HTML][HTML] Bugs on Drugs: Paracetamol Exposure Reveals Genotype-Specific Generational Effects on Life History Traits in Drosophila melanogaster

BNRG Hundebøl, PD Rohde, TN Kristensen… - Insects, 2024 - mdpi.com
Simple Summary In this study, we used the vinegar fly, Drosophila melanogaster, as a
genetic model to investigate the potential long-lasting consequences of exposure to …

Untangling the genetic basis of drug response

PD Rohde, TN Kristensen - Pharmacogenomics, 2020 - Taylor & Francis
We are all unique! This is evident in the immediate differences in our appearances, from
variability in individual disease predisposition and disease trajectories, to molecular defined …

Susu Qu1, 2*†, Qingjie Zhu2†, Han Zhou2, Yuan Gao2, Yi Wei2, Yuan Ma2, Zhicheng Wang1, 2, Xueting Sun2, Lei Zhang2, 3, Quanjun Yang4, Lei Kong5 and Li …

BRH Geurten, BH Paffhausen… - Modern Methods in …, 2022 - books.google.com
Drosophila is a powerful genetic animal model for studies of complex phenotypes such as
circadian rhythms, sleep, movement, and diseases (Sokolowski, 2001; Bier, 2005; Bellen et …