Spiro-connected hexahydropyrimidine-2, 4, 6-trione heterocyclic rings have received
increasing attention from the viewpoint of biological activity and synthetic methods due to the …

Spirocyclic compounds fascinate the synthetic chemists due to their privileged ring system
and efficacy in drug discovery. Many natural compounds comprise spirocyclic moiety in their …

The present review deals with the progress in medicinal chemistry of spirocyclic compounds,
a wider class of natural and synthetic organic molecules, defined as a hybrid of two …

An efficient and recyclable homogeneous catalyst is developed using commercially cheap l-
proline and melamine for the synthesis of chromenes and spirochromenes (spirooxindoles) …

Organic reactions “On water” is a rapidly develo** area over the past few years. Many
important classes of reactions like cross‐coupling reactions, pericyclic reactions, C− H …

This microreview highlights the utility of 1, 4‐dithiane‐2, 5‐diol (1) as a source for the in situ
generation of 2‐mercaptoacetaldehyde (2), a versatile two‐carbon synthon featuring both …

A highly efficient domino aza-MIRC (Michael Induced Ring Closure) reaction between
barbiturate-derived alkenes and N-alkoxy α-haloamides has been achieved in moderate to …

Spiro compounds being multi-cyclic systems linked by a single atom, have distinct three
dimensionalities, and prominently hold a position of interest in the fields of synthetic and …

The organobase-mediated diastereoselective spirocyclopropanation of barbiturate-based
olefins with 2, 4-disubstituted benzyl chlorides has been developed. The reactions were …

Heterocyclic compounds are well‐known for their use in the synthesis of drugs and drug
intermediates. This review provides a systematic survey on the chemical synthesis of …