Tau is well established as a microtubule-associated protein in neurons. However, under
pathological conditions, aberrant assembly of tau into insoluble aggregates is accompanied …

Eukaryotic cells have been confronted throughout their evolution with potentially lethal
plasma membrane injuries, including those caused by osmotic stress, by infection from …

Calpains are a family of proteases that were scientifically recognized earlier than
proteasomes and caspases, but remain enigmatic. However, they are known to participate in …

Calpain is an intracellular Ca2+-dependent cysteine protease (EC 3.4. 22.17; Clan CA,
family C02). Recent expansion of sequence data across the species definitively shows that …

The calpain family of proteases has been implicated in cellular processes such as
apoptosis, proliferation and cell migration. Calpains are involved in several key aspects of …

In brain ischemia, gating of postsynaptic glutamate receptors and other membrane channels
triggers intracellular Ca 2+ overload and cell death. In excitotoxic settings, the initial Ca 2+ …

Accurate diagnosis for mild traumatic brain injury (mTBI) remains challenging, as prognosis
and return-to-play/work decisions are based largely on patient reports. Numerous …

A recent major conceptual advance has been the recognition of the importance of immune
system–neuronal interactions in the modulation of brain function, one example of which is …

Calpain is a ubiquitous calcium-sensitive protease that is essential for normal physiologic
neuronal function. However, alterations in calcium homeostasis lead to persistent …

The translocation of apoptosis-inducing factor (AIF) from mitochondria to the nucleus has
been implicated in the mechanism of glutamate excitotoxicity in cortical neurons and has …