A spotlight on the interplay of signaling pathways and the role of miRNAs in osteosarcoma pathogenesis and therapeutic resistance

AS Doghish, M Hegazy, A Ismail, HA El-Mahdy… - … -Research and Practice, 2023 - Elsevier
Osteosarcoma (OS) is one of the most common bone cancers that constantly affects
children, teenagers, and young adults. Numerous epigenetic elements, such as miRNAs …

Current status and prospects of clinical treatment of osteosarcoma

ZY Jiang, JB Liu, XF Wang, YS Ma… - Technology in cancer …, 2022 - journals.sagepub.com
Osteosarcoma, one of the common malignant tumors in the skeletal system, originates in
mesenchymal tissue, and the most susceptible area of occurrence is the metaphysis with its …

MicroRNAs; their therapeutic and biomarker properties

S Azizi Dargahlou, M Iriti, M Pouresmaeil… - Cellular, Molecular …, 2023 - cmbr-journal.com
MicroRNAs (miRNAs) are, small (roughly 19–25 nucleotides in length), conserved, non-
coding, single-stranded, and functional RNA molecules with the properties of gene …

Targeting signaling pathways in osteosarcoma: Mechanisms and clinical studies

Z Ji, J Shen, Y Lan, Q Yi, H Liu - MedComm, 2023 - Wiley Online Library
Osteosarcoma (OS) is a highly prevalent bone malignancy among adolescents, accounting
for 40% of all primary malignant bone tumors. Neoadjuvant chemotherapy combined with …

Anti-invasive and anti-migratory effects of ononin on human osteosarcoma cells by limiting the MMP2/9 and EGFR-Erk1/2 pathway

G Gong, K Ganesan, Q **ong, Y Zheng - Cancers, 2023 - mdpi.com
Simple Summary Osteosarcoma is the most prevalent orthotopic bone tumor. Due to its high
metastatic properties, it has become the leading cause of cancer death worldwide. At this …

Zinc oxide nanoparticles and cancer chemotherapy: Helpful tools for enhancing chemo-sensitivity and reducing side effects?

M Vaghari-Tabari, D Jafari-Gharabaghlou… - … Trace Element Research, 2024 - Springer
Cancer chemotherapy is still a serious challenge. Chemo-resistance and destructive side
effects of chemotherapy drugs are the most critical limitations of chemotherapy. Chemo …

Nanostructured system based on hydroxyapatite and curcumin: A promising candidate for osteosarcoma therapy

JPN Marinho, NP Neme, MJ de Souza Matos… - Ceramics …, 2023 - Elsevier
Osteosarcoma is the most common type of bone cancer. Despite therapeutic progress,
survival rates for metastatic cases or that do not respond well to chemotherapy remain in the …

[HTML][HTML] Research progress on the role of lncRNA, circular RNA, and microRNA networks in regulating ferroptosis in osteosarcoma

C Yan, Y Dou, R **a, S Liu, J Fu, D Li, R Wang… - Biomedicine & …, 2024 - Elsevier
Noncoding RNAs (ncRNAs) do not participate in protein-coding. Ferroptosis is a newly
discovered form of cell death mediated by reactive oxygen species and lipid peroxidation …

[HTML][HTML] MAT2A inhibits the ferroptosis in osteosarcoma progression regulated by miR-26b-5p

S **a, Y Liang, Y Shen, W Zhong, Y Ma - Journal of Bone Oncology, 2023 - Elsevier
Osteosarcoma (OS) is the most frequent primary malignant bone tumor. Ferroptosis, a form
of regulated cell death, is a key tumor suppression mechanism. Although methionine …

Target recycle initiated entropy driven assembly strategy for sensitive, enzyme-free, and portable miRNA detection

Z Jiang, Z Liu - Analytical Biochemistry, 2024 - Elsevier
MicroRNA (miRNA) is a pivotal biomarker in the diagnosis of various cancers, including
bladder cancer (BCa). Despite their significance, the low abundance of miRNA presents a …