Effects of metformin on weight loss: potential mechanisms

SK Malin, SR Kashyap - Current Opinion in Endocrinology …, 2014 - journals.lww.com
Metformin induces modest weight loss in overweight and obese individuals at risk for
diabetes. A more detailed understanding of how metformin induces weight loss will likely …

Impact of dietary macronutrient distribution on BMI and cardiometabolic outcomes in overweight and obese children and adolescents: a systematic review

ML Gow, M Ho, TL Burrows, LA Baur, L Stewart… - Nutrition …, 2014 - academic.oup.com
The present systematic review examined the effectiveness of weight management
interventions comparing diets with varying macronutrient distributions on BMI and …

[PDF][PDF] Appraisal of clinical care practices for child obesity treatment. Part I: interventions

AC Skinner, AE Staiano, SC Armstrong, SL Barkin… - …, 2023 - edu.endocrincentr.ru
The objective of this technical report is to provide clinicians with evidence-based, actionable
information upon which to make assessment and treatment decisions for children and …

Bioelectrical impedance analysis to estimate body composition, and change in adiposity, in overweight and obese adolescents: comparison with dual-energy x-ray …

CS Wan, LC Ward, J Halim, ML Gow, M Ho, JN Briody… - BMC pediatrics, 2014 - Springer
Background There is a need for a practical, inexpensive method to assess body composition
in obese adolescents. This study aimed to 1) compare body composition parameters …

Metformin for prevention or delay of type 2 diabetes mellitus and its associated complications in persons at increased risk for the development of type 2 diabetes …

KS Madsen, Y Chi, MI Metzendorf… - Cochrane Database …, 2019 - cochranelibrary.com
Background The projected rise in the incidence of type 2 diabetes mellitus (T2DM) could
develop into a substantial health problem worldwide. Whether metformin can prevent or …

Pathophysiology and treatment of prediabetes and type 2 diabetes in youth

F Bacha, TS Hannon, M Tosur, JM Pike… - Diabetes …, 2024 - diabetesjournals.org
Youth-onset type 2 diabetes is a heterogeneous disease with increasing prevalence in
relation to increased rates of obesity in children. It has genetic, epigenetic, social, and …

Intermittent energy restriction for adolescents with obesity: the Fast Track to Health randomized clinical trial

NB Lister, LA Baur, ET House, S Alexander… - JAMA …, 2024 - jamanetwork.com
Importance Adolescent obesity requires effective and accessible treatment. Intensive dietary
interventions have the potential to be used as adjunctive therapy for behavioral weight …

Evaluation and treatment of prediabetes in youth

SN Magge, J Silverstein, D Elder, K Nadeau… - The Journal of …, 2020 - jpeds.com
The increased prevalence of pediatric obesity has led to an increased incidence and
prevalence of type 2 diabetes mellitus (T2DM), as well as the intermediate condition of …

[HTML][HTML] Intermittent energy restriction is a feasible, effective, and acceptable intervention to treat adolescents with obesity

H Jebeile, ML Gow, NB Lister, MM Haghighi, J Ayer… - The Journal of …, 2019 - Elsevier
Background Intermittent energy restriction (IER) is an effective obesity management strategy
in adults. Objective The aim of this study was to investigate the feasibility, effectiveness, and …

Early insulin resistance, type 2 diabetes, and treatment options in childhood

N Polidori, F Mainieri, F Chiarelli, A Mohn… - Hormone research in …, 2022 - karger.com
Abstract Background: Type 2 diabetes (T2D) represents just the tip of the iceberg of the
complex metabolic alterations associated with obesity and other clinical conditions …