The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases

AP Simopoulos - Experimental biology and medicine, 2008 - journals.sagepub.com
Several sources of information suggest that human beings evolved on a diet with a ratio of
omega-6 to omega-3 essential fatty acids (EFA) of~ 1 whereas in Western diets the ratio is …

Alpha‐linolenic acid: an omega‐3 fatty acid with neuroprotective properties—ready for use in the stroke clinic?

N Blondeau, RH Lipsky, M Bourourou… - BioMed research …, 2015 - Wiley Online Library
Alpha‐linolenic acid (ALA) is plant‐based essential omega‐3 polyunsaturated fatty acids
that must be obtained through the diet. This could explain in part why the severe deficiency …

Plasma phospholipid fatty acids and prostate cancer risk in the SELECT trial

TM Brasky, AK Darke, X Song… - Journal of the …, 2013 - academic.oup.com
Background Studies of dietary ω-3 fatty acid intake and prostate cancer risk are inconsistent;
however, recent large prospective studies have found increased risk of prostate cancer …

Nutrigenomics: Epigenetics and cancer prevention: A comprehensive review

A Nasir, MMH Bullo, Z Ahmed, A Imtiaz… - Critical reviews in …, 2022 - Taylor & Francis
Due to change in lifestyle and food habits, people are more at risk of diet-related diseases
and cancers. It is also established that dietary modifications significantly reduce the risk of …

Multi-targeted therapy of cancer by omega-3 fatty acids

IM Berquin, IJ Edwards, YQ Chen - Cancer letters, 2008 - Elsevier
Omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFAs) are essential fatty
acids necessary for human health. Currently, the Western diet contains a disproportionally …

Genetic variants in the metabolism of omega-6 and omega-3 fatty acids: their role in the determination of nutritional requirements and chronic disease risk

AP Simopoulos - Experimental biology and medicine, 2010 - journals.sagepub.com
The tissue composition of polyunsaturated fatty acids is important to health and depends on
both dietary intake and metabolism controlled by genetic polymorphisms that should be …

[HTML][HTML] The omega-6/omega-3 fatty acid ratio: health implications

AP Simopoulos - Oléagineux, Corps gras, Lipides, 2010 - ocl-journal.org
Today, Western diets are characterized by a higher omega-6 and a lower omega-3 fatty acid
intake, whereas during the Paleolithic period when human's genetic profile was established …

[PDF][PDF] The omega-6/omega-3 fatty acid ratio, genetic variation, and cardiovascular disease.

AP Simopoulos - Asia Pacific journal of clinical nutrition, 2008 - apjcn.nhri.org.tw
A high omega-6/omega-3 ratio, as is found in today's Western diets, promotes the
pathogenesis of many chronic diseases, including cardiovascular disease. Increased dietary …

[HTML][HTML] Fish consumption and prostate cancer risk: a review and meta-analysis

KM Szymanski, DC Wheeler, LA Mucci - The American journal of clinical …, 2010 - Elsevier
Background: Prostate cancer incidence varies 60-fold globally, which suggests the roles of
lifestyle and dietary factors in its cause. To our knowledge, a comprehensive assessment of …

Evolutionary aspects of the dietary omega-6/omega-3 fatty acid ratio: medical implications

AP Simopoulos - Evolutionary Thinking in Medicine: From Research to …, 2016 - Springer
Several sources of information suggest that humans evolved on a diet with an equal ratio of
omega-6 (ω-6) to omega-3 (ω-3) fatty acids, whereas in today's Western diet, this ratio is …