Atherosclerotic cardiovascular disease results in> 19 million deaths annually, and coronary
heart disease accounts for the majority of this toll. Despite major advances in treatment of …

Coronary atherosclerosis is by far the most frequent cause of ischemic heart disease, and
plaque disruption with superimposed thrombosis is the main cause of the acute coronary …

The notion that heart attacks develop from coronary-artery stenosis is an oversimplification
of a process involving lipid metabolism, inflammation, macrophage activation, collagen …

The majority of patients with acute coronary syndromes (ACS) present with unstable angina,
acute myocardial infarction, and sudden coronary death. The most common cause of …

Atherosclerosis is a maladaptive, nonresolving chronic inflammatory disease that occurs at
sites of blood flow disturbance. The disease usually remains silent until a breakdown of …

Although mortality rates from coronary heart disease in the western countries have declined
in the last few decades, morbidity caused by this disease is increasing and a substantial …

Vascular remodeling, defined as any enduring change in the size and/or composition of an
adult blood vessel, allows adaptation and repair. On the other hand, inappropriate …

▪ Abstract Statins are potent inhibitors of cholesterol biosynthesis. In clinical trials, statins are
beneficial in the primary and secondary prevention of coronary heart disease. However, the …

Today's concept of vulnerable plaque has evolved primarily from the early pioneering work
uncovering the pivotal role of plaque rupture and coronary thrombosis as the major cause of …

There are conflicting reports concerning the tissue reaction of small animals to porcine-
based, non-cross-linked collagen I–III membranes/matrices for use in guided tissue/bone …