Reactive oxygen species (ROS) contribute to several aspects of vascular diseases including
ischemia–reperfusion injury, scavenging of nitric oxide, or stimulation of inflammation and …

The vascular endothelium plays a crucial role in regulating normal blood vessel physiology.
The gene products responsible are commonly expressed exclusively, or preferentially, in …

Abstract Classical (M1) and alternative (M2) polarization of mononuclear cells (MNCs) such
as monocyte and macrophages is known to occur in response to challenges within a …

Stem cells are a central feature of metazoan biology. Haematopoietic stem cells (HSCs)
represent the best‐characterized example of this phenomenon, but the molecular …

Objective—Angiopoietin-2 (Ang-2) is a non-signal transducing ligand of the endothelial
receptor tyrosine kinase Tie-2. Ang-2 is produced by endothelial cells and acts as an …

The ETS (E 26 T ransformation-specific S equence) factors are comprised of a family of
transcription factors that share a highly conserved DNA binding domain. Although originally …

• Introduction• Background, structural characteristics and distribution of Tie2• Background,
structural characteristics and distribution of Ang‐1• Regulation of Tie2 signalling• …

ERG is a member of the ETS transcription factor family that is highly enriched in endothelial
cells (ECs). To further define the role of ERG in regulating EC function, we evaluated the …

At least thirteen ETS-domain transcription factors are expressed during embryonic
hematopoietic or vascular development and potentially function in the formation and …

Transcription factors of the ETS family are important regulators of endothelial gene
expression. Here, we review the evidence that ETS factors regulate angiogenesis and briefly …