Severe malaria has a high mortality rate (15–20%) despite treatment with effective
antimalarial drugs. Adjunctive therapies for severe malaria that target the underlying disease …

▪ Abstract Many pathogens that either rely on an insect vector to complete their life cycle (eg,
Trypanosoma spp. and Borrelia spp.) or exist in a unique ecological niche where …

CD36 is a scavenger receptor involved in fatty acid metabolism, innate immunity and
angiogenesis. It interacts with lipoprotein particles and facilitates uptake of long chain fatty …

Understanding the targets and mechanisms of human immunity to malaria caused by
Plasmodium falciparum is crucial for advancing effective vaccines and develo** tools for …

Human infections with Plasmodium falciparum may result in severe forms of malaria. The
widespread and rapid development of drug resistance in P. falciparum and the resistance of …

The Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) family of
cytoadherent proteins has a central role in disease from malaria infection. This highly …

Binding of infected erythrocytes to brain venules is a central pathogenic event in the lethal
malaria disease complication, cerebral malaria. The only parasite adhesion trait linked to …

The sequestration of Plasmodium falciparum–infected red blood cells (irbcs) in the
microvasculature of organs is associated with severe disease; correspondingly, the …

Infected erythrocytes containing the more mature stages of the human malaria Plasmodium
falciparum may adhere to endothelial cells and uninfected red cells. These phenomena …

The Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family has a key role
in parasite survival, transmission, and virulence. PfEMP1 are exported to the erythrocyte …