Cell migration plays a central role in a wide variety of biological phenomena. In
embryogenesis, cellular migrations are a recurring theme in important morphogenic …

Many cell phenomena that involve shape changes are affected by the intrinsic deformability
of the plasma membrane (PM). Far from being a passive participant, the PM is now known to …

To move forward, migrating cells must generate traction forces through surface receptors
bound to extracellular matrix molecules coupled to a rigid structure. We investigated whether …

In eukaryotic cells directional sensing is mediated by heterotrimeric guanine nucleotide–
binding protein (G protein)–linked signaling pathways. In Dictyostelium discoideum …

The morphological term 'amoeboid'migration subsumes a number of rather distinct
biophysical modes of cellular locomotion that range from blebbing motility to entirely actin …

Little is known about how neutrophils and other cells establish a single zone of actin
assembly during migration. A widespread assumption is that the leading edge prevents …

While the protrusive event of cell locomotion is thought to be driven by actin polymerization,
the mechanism of forward translocation of the cell body is unclear. To elucidate the …

Like neutrophilic leukocytes, differentiated HL-60 cells respond to chemoattractant by
adopting a polarized morphology, with F-actin in a protruding pseudopod at the leading …

Chemotaxis, the directed migration of cells in chemical gradients, is a vital process in normal
physiology and in the pathogenesis of many diseases. Chemotactic cells display motility …

In nature, microorganisms must often cope with hostile environmental conditions. To do so
they have developed sophisticated cooperative behaviour and intricate communication …