Directed cell migration is a physical process that requires dramatic changes in cell shape
and adhesion to the extracellular matrix. For efficient movement, these processes must be …

The morphological term 'amoeboid'migration subsumes a number of rather distinct
biophysical modes of cellular locomotion that range from blebbing motility to entirely actin …

The interplay between the mechanical properties of cells and the forces that they produce
internally or that are externally applied to them play an important role in maintaining the …

Cells engage in mechanical force exchange with their extracellular environment through
tension generated by the cytoskeleton. A method combining laser scanning confocal …

Cell motility is required for diverse biological processes including development, homing of
immune cells, wound healing, and cancer cell invasion. Motile neutrophils exhibit a …

During cell migration, forces generated by the actin cytoskeleton are transmitted through
adhesion complexes to the substrate. To investigate the mechanism of force generation and …

Progress in the field of nanoparticles has enabled the rapid development of multiple
products and technologies; however, some nanoparticles can pose both a threat to the …

The recirculation of leukocytes is essential for proper immune responses. However, the
molecular mechanisms that regulate the entry of leukocytes into the lymphatics remain …

We have found that MLC-dependent activation of myosin IIB in migrating cells is required to
form an extended rear, which coincides with increased directional migration. Activated …

Vinculin is a cytoplasmic actin-binding protein enriched in focal adhesions and adherens
junctions that is essential for embryonic development. Much is now known regarding the role …