The development of single-cell and spatial transcriptomics methods was instrumental in the
conception of the Human Cell Atlas initiative, which aims to generate an integrated map of …

As the professional antigen-presenting cells of the immune system, dendritic cells (DCs)
sense the microenvironment and shape the ensuing adaptive immune response. DCs can …

Improvements in tumor immunotherapies depend on better understanding of the anti-tumor
T cell response. By studying human tumor-draining lymph nodes (TDLNs), we found that …

Glioblastomas are aggressive primary brain cancers that recur as therapy-resistant tumors.
Myeloid cells control glioblastoma malignancy, but their dynamics during disease …

Checkpoint blockade therapies have improved cancer treatment, but such immunotherapy
regimens fail in a large subset of patients. Conventional type 1 dendritic cells (DC1s) control …

Cancer immunotherapies targeting adaptive immune checkpoints have substantially
improved patient outcomes across multiple metastatic and treatment-refractory cancer types …

The immune microenvironment of hepatocellular carcinoma (HCC) is poorly characterized.
Combining two single-cell RNA sequencing technologies, we produced transcriptomes of …

Dendritic cells (DCs) play a critical role in orchestrating adaptive immune responses due to
their unique ability to initiate T cell responses and direct their differentiation into effector …

Dendritic cells (DCs) can be viewed as translators between innate and adaptive immunity.
They integrate signals derived from tissue infection or damage and present processed …

Immunotherapy is a promising treatment for triple-negative breast cancer (TNBC), but
patients relapse, highlighting the need to understand the mechanisms of resistance. We …