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Microfluidic epigenomic map** technologies for precision medicine
Epigenomic map** of tissue samples generates critical insights into genome-wide
regulations of gene activities and expressions during normal development and disease …
regulations of gene activities and expressions during normal development and disease …
Single-molecule study reveals Hmo1, not Hho1, promotes chromatin assembly in budding yeast
Linker histone H1 plays a crucial role in various biological processes, including nucleosome
stabilization, high-order chromatin structure organization, gene expression, and epigenetic …
stabilization, high-order chromatin structure organization, gene expression, and epigenetic …
Archaeal chromatin proteins Cren7 and Sul7d compact DNA by bending and bridging
Archaeal chromatin proteins Cren7 and Sul7d from Sulfolobus are DNA benders. To better
understand their architectural roles in chromosomal DNA organization, we analyzed DNA …
understand their architectural roles in chromosomal DNA organization, we analyzed DNA …
Utilizing biotinylated proteins expressed in yeast to visualize DNA–protein interactions at the single-molecule level
Much of our knowledge in conventional biochemistry has derived from bulk assays.
However, many stochastic processes and transient intermediates are hidden when …
However, many stochastic processes and transient intermediates are hidden when …
Kinetic analysis of DNA compaction by mycobacterial integration host factor at the single-molecule level
Nucleoid-associated proteins (NAPs) play an important role on chromosome condensation
and organization. Mycobacterial integration host factor (mIHF) is one of the few …
and organization. Mycobacterial integration host factor (mIHF) is one of the few …
Visualizing the interaction between the Qdot-labeled protein and site-specifically modified Λ DNA at the single molecule level
The fluorescence microscopy has made great contributions in dissecting the mechanisms of
complex biological processes at the single molecule level. In single molecule assays for …
complex biological processes at the single molecule level. In single molecule assays for …
Yeast nucleoplasmic extracts and an application to visualize chromatin assembly on single molecules of DNA
In eukaryotic cells, the genomic DNA is packaged into chromatin, the basic unit of which is
the nucleosome. Studying the mechanism of chromatin formation under physiological …
the nucleosome. Studying the mechanism of chromatin formation under physiological …
Nonequilibrium and nonlinear kinetics as key determinants for bistability in fission yeast G2-M transition
A living cell is an open, nonequilibrium biochemical system where ATP hydrolysis serves as
the energy source for a wide range of intracellular processes, possibly including the …
the energy source for a wide range of intracellular processes, possibly including the …