Linker histone H1 plays a crucial role in various biological processes, including nucleosome
stabilization, high-order chromatin structure organization, gene expression, and epigenetic …

Epigenomic map** of tissue samples generates critical insights into genome-wide
regulations of gene activities and expressions during normal development and disease …

Archaeal chromatin proteins Cren7 and Sul7d from Sulfolobus are DNA benders. To better
understand their architectural roles in chromosomal DNA organization, we analyzed DNA …

Much of our knowledge in conventional biochemistry has derived from bulk assays.
However, many stochastic processes and transient intermediates are hidden when …

The living cell is an open nonequilibrium biochemical system, where ATP hydrolysis serves
as the energy source for a wide range of intracellular processes including the assurance for …

Nucleoid-associated proteins (NAPs) play an important role on chromosome condensation
and organization. Mycobacterial integration host factor (mIHF) is one of the few …

The fluorescence microscopy has made great contributions in dissecting the mechanisms of
complex biological processes at the single molecule level. In single molecule assays for …

In eukaryotic cells, the genomic DNA is packaged into chromatin, the basic unit of which is
the nucleosome. Studying the mechanism of chromatin formation under physiological …