Signaling pathways in brain tumors and therapeutic interventions
S Li, C Wang, J Chen, Y Lan, W Zhang… - … and Targeted Therapy, 2023 - nature.com
Brain tumors, although rare, contribute to distinct mortality and morbidity at all ages.
Although there are few therapeutic options for brain tumors, enhanced biological …
Although there are few therapeutic options for brain tumors, enhanced biological …
Molecular alterations in meningioma: prognostic and therapeutic perspectives
The mutational landscape of meningioma has expanded following the use of the new
genetic sequencing approaches. Novel mutations have been characterized and reveal their …
genetic sequencing approaches. Novel mutations have been characterized and reveal their …
Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities
Meningiomas are the most common primary intracranial tumors. There are no effective
medical therapies for meningioma patients, and new treatments have been encumbered by …
medical therapies for meningioma patients, and new treatments have been encumbered by …
Integrated molecular-morphologic meningioma classification: a multicenter retrospective analysis, retrospectively and prospectively validated
PURPOSE Meningiomas are the most frequent primary intracranial tumors. Patient outcome
varies widely from benign to highly aggressive, ultimately fatal courses. Reliable …
varies widely from benign to highly aggressive, ultimately fatal courses. Reliable …
The genomic and transcriptional landscape of primary central nervous system lymphoma
Primary lymphomas of the central nervous system (PCNSL) are mainly diffuse large B-cell
lymphomas (DLBCLs) confined to the central nervous system (CNS). Molecular drivers of …
lymphomas (DLBCLs) confined to the central nervous system (CNS). Molecular drivers of …
Associations of meningioma molecular subgroup and tumor recurrence
Background We and others have identified mutually exclusive molecular subgroups of
meningiomas; however, the implications of this classification for clinical prognostication …
meningiomas; however, the implications of this classification for clinical prognostication …
Multiple approaches converge on three biological subtypes of meningioma and extract new insights from published studies
One-fifth of meningiomas classified as benign by World Health Organization (WHO)
histopathological grading will behave malignantly. To better diagnose these tumors, several …
histopathological grading will behave malignantly. To better diagnose these tumors, several …
Multiplatform genomic profiling and magnetic resonance imaging identify mechanisms underlying intratumor heterogeneity in meningioma
Meningiomas are the most common primary intracranial tumors, but the molecular drivers of
meningioma tumorigenesis are poorly understood. We hypothesized that investigating …
meningioma tumorigenesis are poorly understood. We hypothesized that investigating …
Distinct genomic subclasses of high-grade/progressive meningiomas: NF2-associated, NF2-exclusive, and NF2-agnostic
Background Genomic studies of high-grade/progressive meningiomas have reported a
heterogeneous mutation spectrum, identifying few recurrently mutated genes. Most studies …
heterogeneous mutation spectrum, identifying few recurrently mutated genes. Most studies …
Hypermitotic meningiomas harbor DNA methylation subgroups with distinct biological and clinical features
Background Meningiomas, the most common primary intracranial tumors, can be separated
into 3 DNA methylation groups with distinct biological drivers, clinical outcomes, and …
into 3 DNA methylation groups with distinct biological drivers, clinical outcomes, and …