Inherited susceptibility to common cancers
WD Foulkes - New England Journal of Medicine, 2008 - Mass Medical Soc
This review deals with germ-line genes that increase susceptibility to five major types of
cancer: breast, lung, pancreatic, prostate, and colorectal cancer. Often familial, often …
cancer: breast, lung, pancreatic, prostate, and colorectal cancer. Often familial, often …
[HTML][HTML] Genetic susceptibility to breast cancer
Genetic and lifestyle/environmental factors are implicated in the aetiology of breast cancer.
This review summarizes the current state of knowledge on rare high penetrance mutations …
This review summarizes the current state of knowledge on rare high penetrance mutations …
A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1)
We conducted a three-stage genome-wide association study (GWAS) of breast cancer in
9,770 cases and 10,799 controls in the Cancer Genetic Markers of Susceptibility (CGEMS) …
9,770 cases and 10,799 controls in the Cancer Genetic Markers of Susceptibility (CGEMS) …
RNF146 is a poly (ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling
Y Zhang, S Liu, C Mickanin, Y Feng, O Charlat… - Nature cell …, 2011 - nature.com
The Wnt/β-catenin signalling pathway plays essential roles in embryonic development and
adult tissue homeostasis, and deregulation of this pathway has been linked to cancer. Axin …
adult tissue homeostasis, and deregulation of this pathway has been linked to cancer. Axin …
Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25. 1
W Zheng, J Long, YT Gao, C Li, Y Zheng, YB ** hereditary breast cancer is germline mutations
occurring in breast cancer (BCs) susceptibility genes, for example, BRCA1, BRCA2, TP53 …
occurring in breast cancer (BCs) susceptibility genes, for example, BRCA1, BRCA2, TP53 …
Hereditary breast cancer: new genetic developments, new therapeutic avenues
Six genes confer a high risk for develo** breast cancer (BRCA1/2, TP53, PTEN, STK11,
CDH1). Both BRCA1 and BRCA2 have DNA repair functions, and BRCA1/2 deficient tumors …
CDH1). Both BRCA1 and BRCA2 have DNA repair functions, and BRCA1/2 deficient tumors …
Genetic predisposition to breast cancer: past, present, and future
In recent years, our understanding of genetic predisposition to breast cancer has advanced
significantly. Three classes of predisposition factors, categorized by their associated risks of …
significantly. Three classes of predisposition factors, categorized by their associated risks of …
Cancer PRSweb: an online repository with polygenic risk scores for major cancer traits and their evaluation in two independent biobanks
To facilitate scientific collaboration on polygenic risk scores (PRSs) research, we created an
extensive PRS online repository for 35 common cancer traits integrating freely available …
extensive PRS online repository for 35 common cancer traits integrating freely available …
Genetic variants associated with breast-cancer risk: comprehensive research synopsis, meta-analysis, and epidemiological evidence
Background More than 1000 reports have been published in the past two decades on
associations between variants in candidate genes and risk of breast cancer. Results have …
associations between variants in candidate genes and risk of breast cancer. Results have …