Current trends on solid dispersions: past, present, and future

R Malkawi, WI Malkawi, Y Al-Mahmoud… - Advances in …, 2022 - Wiley Online Library
Solid dispersions have achieved significant interest as an effective means of enhancing the
dissolution rate and thus the bioavailability of a range of weakly water‐soluble drugs. Solid …

Recent trends in praziquantel nanoformulations for helminthiasis treatment

AC Mengarda, B Iles, JP F. Longo… - Expert Opinion on Drug …, 2022 - Taylor & Francis
Introduction Infections caused by parasitic flatworms impose a considerable worldwide
health burden. Recently, World Health Organization launched its roadmap for neglected …

Lipid-based solubilization technology via hot melt extrusion: Promises and challenges

O Zupančič, M Spoerk, A Paudel - Expert Opinion on Drug Delivery, 2022 - Taylor & Francis
Introduction Self-emulsifying drug delivery systems (SEDDS) are a promising strategy to
improve the oral bioavailability of poorly water-soluble drugs (PWSD). However, poor drug …

Spray congealing: An emerging technology to prepare solid dispersions with enhanced oral bioavailability of poorly water soluble drugs

S Bertoni, B Albertini, N Passerini - Molecules, 2019 - mdpi.com
The low and variable oral bioavailability of poorly water soluble drugs remains a major
concern for the pharmaceutical industry. Spray congealing is an emerging technology for the …

Preformulation and Long-Term Stability Studies of an Optimized Palatable Praziquantel Ethanol-Free Solution for Pediatric Delivery

G Bedogni, P Garcia, K Seremeta, N Okulik, C Salomon - Pharmaceutics, 2023 - mdpi.com
To date, the treatment for cysticercosis and neurocysticercosis consists of a single oral
intake of praziquantel (5–10 mg/kg), which since it is only available as tablets, hinders its …

Better and greener: sustainable pharmaceutical manufacturing technologies for highly bioavailable solid dosage forms

S Bertoni, D Hasa, B Albertini, B Perissutti… - Drug Delivery and …, 2022 - Springer
In the last decades, Green Chemistry has been gaining widespread attention within the
pharmaceutical field. It is thus very important to bring more sustainable approaches into the …

Paediatric formulation: Design and development

A Lopalco, N Denora - International Journal of Molecular Sciences, 2020 - mdpi.com
The development of medicines designed for children can be challenging since this distinct
patient population requires specific needs. A formulation designed for paediatric patients …

Solid dispersions of anthelmintics and plant protection preparations

SS Khalikov - Solids, 2021 - mdpi.com
Because of the rapid development of nanotechnologies, materials, in particular, solid
dispersions (SDs), which are actively introduced into the life of modern man, have been …

Product contamination during mechanochemical synthesis of praziquantel co-crystal, polymeric dispersion and cyclodextrin complex

J Jablan, E Marguí, L Posavec, D Klarić… - … of pharmaceutical and …, 2024 - Elsevier
This paper aims to evaluate the product contamination by elemental impurities during the
mechanochemical synthesis of praziquantel (PZQ) co-crystal, polymeric dispersion and …

Therapeutic applications of solid dispersions for drugs and new molecules: In vitro and in vivo activities

VS Oliveira, AS de Almeida, IS Albuquerque… - Pharmaceutics, 2020 - mdpi.com
This review aims to provide an overview of studies that address the use, in therapeutic
applications, of solid dispersions (SDs) with biological activities in vitro and/or in vivo mainly …