Role of dietary fructose and hepatic de novo lipogenesis in fatty liver disease

S Softic, DE Cohen, CR Kahn - Digestive diseases and sciences, 2016 - Springer
Nonalcoholic fatty liver disease (NAFLD) is a liver manifestation of metabolic syndrome.
Overconsumption of high-fat diet (HFD) and increased intake of sugar-sweetened …

[HTML][HTML] Metabolic effects of fructose and the worldwide increase in obesity

L Tappy, KA Lê - Physiological reviews, 2010 - journals.physiology.org
While virtually absent in our diet a few hundred years ago, fructose has now become a major
constituent of our modern diet. Our main sources of fructose are sucrose from beet or cane …

The small intestine converts dietary fructose into glucose and organic acids

C Jang, S Hui, W Lu, AJ Cowan, RJ Morscher, G Lee… - Cell metabolism, 2018 - cell.com
Excessive consumption of sweets is a risk factor for metabolic syndrome. A major chemical
feature of sweets is fructose. Despite strong ties between fructose and disease, the …

Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease

JE Lambert, MA Ramos–Roman, JD Browning… - Gastroenterology, 2014 - Elsevier
Background & Aims There have been few studies of the role of de novo lipogenesis in the
development of nonalcoholic fatty liver disease (NAFLD). We used isotope analyses to …

Dietary sugars intake and cardiovascular health: a scientific statement from the American Heart Association

RK Johnson, LJ Appel, M Brands, BV Howard… - Circulation, 2009 - Am Heart Assoc
High intakes of dietary sugars in the setting of a worldwide pandemic of obesity and
cardiovascular disease have heightened concerns about the adverse effects of excessive …

Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intake

L Hodson, CM Skeaff, BA Fielding - Progress in lipid research, 2008 - Elsevier
Accurate assessment of fat intake is essential to examine the relationships between diet and
disease risk but the process of estimating individual intakes of fat quality by dietary …

Consumption of ultra-processed food products and its effects on children's lipid profiles: a longitudinal study

F Rauber, PDB Campagnolo, DJ Hoffman… - Nutrition, Metabolism and …, 2015 - Elsevier
Abstract Background and Aims Cardiovascular disease development is related to known risk
factors (such as diet and blood lipids) that begin in childhood. Among dietary factors, the …

Fructose-and sucrose-but not glucose-sweetened beverages promote hepatic de novo lipogenesis: A randomized controlled trial

B Geidl-Flueck, M Hochuli, Á Németh, A Eberl… - Journal of …, 2021 - Elsevier
Background & aims Excessive fructose intake is associated with increased de novo
lipogenesis, blood triglycerides, and hepatic insulin resistance. We aimed to determine …

From NAFLD to NASH to cirrhosis—new insights into disease mechanisms

A Wree, L Broderick, A Canbay, HM Hoffman… - Nature reviews …, 2013 - nature.com
NAFLD has evolved as a serious public health problem in the USA and around the world. In
fact, NASH—the most serious form of NAFLD—is predicted to become the leading cause of …

Fructose consumption, lipogenesis, and non-alcoholic fatty liver disease

KW Ter Horst, MJ Serlie - Nutrients, 2017 - mdpi.com
Increased fructose consumption has been suggested to contribute to non-alcoholic fatty liver
disease (NAFLD), dyslipidemia, and insulin resistance, but a causal role of fructose in these …