Biology of Acinetobacter baumannii: Pathogenesis, Antibiotic Resistance Mechanisms, and Prospective Treatment Options

CR Lee, JH Lee, M Park, KS Park, IK Bae… - Frontiers in cellular …, 2017 - frontiersin.org
Acinetobacter baumannii is undoubtedly one of the most successful pathogens responsible
for hospital-acquired nosocomial infections in the modern healthcare system. Due to the …

Immune modulation by bacterial outer membrane vesicles

M Kaparakis-Liaskos, RL Ferrero - Nature Reviews Immunology, 2015 - nature.com
Gram-negative bacteria shed extracellular outer membrane vesicles (OMVs) during their
normal growth both in vitro and in vivo. OMVs are spherical, bilayered membrane …

Designing of multi-epitope peptide vaccine against Acinetobacter baumannii through combined immunoinformatics and protein interaction–based approaches

J Dey, SR Mahapatra, PK Singh… - Immunologic …, 2023 - Springer
Acinetobacter baumannii is one of the major pathogenic ESKAPE bacterium, which is
responsible for about more than 722,000 cases in a year, globally. Despite the alarming …

Engineered bacterial membrane vesicles are promising carriers for vaccine design and tumor immunotherapy

Q Long, P Zheng, X Zheng, W Li, L Hua, Z Yang… - Advanced drug delivery …, 2022 - Elsevier
Bacterial membrane vesicles (BMVs) have emerged as novel and promising platforms for
the development of vaccines and immunotherapeutic strategies against infectious and …

Bacterial membrane vesicles for vaccine applications

N Krishnan, LJ Kubiatowicz, M Holay, J Zhou… - Advanced Drug Delivery …, 2022 - Elsevier
Vaccines have been highly successful in the management of many diseases. However,
there are still numerous illnesses, both infectious and noncommunicable, for which there are …

A critical systematic review of extracellular vesicle clinical trials

RR Mizenko, M Feaver, BT Bozkurt… - Journal of …, 2024 - Wiley Online Library
This systematic review examines the landscape of extracellular vesicle (EV)‐related clinical
trials to elucidate the field's trends in clinical applications and EV‐related methodologies …

Genetically engineered cellular nanoparticles for biomedical applications

N Krishnan, FX Peng, A Mohapatra, RH Fang, L Zhang - Biomaterials, 2023 - Elsevier
In recent years, nanoparticles derived from cellular membranes have been increasingly
explored for the prevention and treatment of human disease. With their flexible design and …

[HTML][HTML] The therapeutic benefit of bacterial membrane vesicles

NJ Bitto, M Kaparakis-Liaskos - International journal of molecular …, 2017 - mdpi.com
The therapeutic potential of extracellular vesicles from eukaryotes has gained strong interest
in recent years. However, research into the therapeutic application of their bacterial …

Subunit vaccines for Acinetobacter baumannii

N Yang, X **, C Zhu, F Gao, Z Weng, X Du… - Frontiers in …, 2023 - frontiersin.org
Acinetobacter baumannii is a gram-negative bacterium and a crucial opportunistic pathogen
in hospitals. A. baumannii infection has become a challenging problem in clinical practice …

Employing Escherichia coli-derived outer membrane vesicles as an antigen delivery platform elicits protective immunity against Acinetobacter baumannii infection

W Huang, S Wang, Y Yao, Y **a, X Yang, K Li, P Sun… - Scientific reports, 2016 - nature.com
Outer membrane vesicles (OMVs) have proven to be highly immunogenic and induced an
immune response against bacterial infection in human clinics and animal models. We …