Cancer arises from genetic alterations that invariably lead to dysregulated transcriptional
programs. These dysregulated programs can cause cancer cells to become highly …

Medulloblastoma (MB) comprises a biologically heterogeneous group of embryonal tumours
of the cerebellum. Four subgroups of MB have been described (WNT, sonic hedgehog …

Medulloblastoma, a malignant childhood cerebellar tumour, segregates molecularly into
biologically distinct subgroups, suggesting that a personalized approach to therapy would …

Current therapies for medulloblastoma, a highly malignant childhood brain tumour, impose
debilitating effects on the develo** child, and highlight the need for molecularly targeted …

Medulloblastoma is a malignant childhood cerebellar tumour type that comprises distinct
molecular subgroups. Whereas genomic characteristics of these subgroups are well …

Background The WHO classification of brain tumours describes 15 subtypes of meningioma.
Nine of these subtypes are allotted to WHO grade I, and three each to grade II and grade III …

Neuroblastoma is a tumor of the peripheral sympathetic nervous system, derived from
multipotent neural crest cells (NCCs). To define core regulatory circuitries (CRCs) controlling …

MYCN amplification drives one in six cases of neuroblastoma. The supernumerary gene
copies are commonly found on highly rearranged, extrachromosomal circular DNA (ecDNA) …

Processive elongation of RNA Polymerase II from a proximal promoter paused state is a rate-
limiting event in human gene control. A small number of regulatory factors influence …

Glioblastoma is the most common and lethal primary malignant brain tumor in adults.
Patients die from recurrent tumors that have become resistant to therapy. New strategies are …