Apoptosis, a form of programmed cell death, is responsible for eliminating damaged or
unnecessary cells in multicellular organisms. Various types of intracellular stress trigger …

Elevated levels of pro-inflammatory cytokines are generally thought to be responsible for
driving the progression of synovial joint inflammation in rheumatoid arthritis (RA) and …

The mitochondrial branched chain aminotransferase-deficient mouse model (BCATm KO),
which exhibits elevated plasma and tissue branched chain amino acids (BCAAs), was used …

Deregulation of apoptosis is associated with various pathologies, such as
neurodegenerative disorders at one end of the spectrum and cancer at the other end …

Ionizing radiation (IR) plays an important role in the treatment of epithelial tumors, such as
lung and prostate cancer, by wounding and killing cancer cells. However, IR also activates …

Photodynamic therapy (PDT) is a method that is used in cancer treatment. The main
therapeutic effect is the production of singlet oxygen (1 O 2). Phthalocyanines for PDT …

Background: Therapeutic peptides have great potential as anticancer agents owing to their
ease of rational design and target specificity. However, their utility in vivo is limited by low …

Apoptosis is an essential process for embryonic and lymphocyte development, immune
system modulation and tissue homeostasis. Defects in apoptotic signaling often lead to …

The binding affinity of a protein–protein interaction is concentrated at amino acids known as
hot spots. It has been suggested that small molecules disrupt protein–protein interactions by …

Abstract Intrinsically Disordered Regions (IDRs) even though they cannot form a defined
three-dimensional structure play a pivotal role in modulating cellular processes and …