Polymeric micelles for the delivery of poorly soluble drugs: From nanoformulation to clinical approval

D Hwang, JD Ramsey, AV Kabanov - Advanced drug delivery reviews, 2020 - Elsevier
Over the last three decades, polymeric micelles have emerged as a highly promising drug
delivery platform for therapeutic compounds. Particularly, poorly soluble small molecules …

Nanoparticle-mediated combination therapy: two-in-one approach for cancer

S Gurunathan, MH Kang, M Qasim, JH Kim - International journal of …, 2018 - mdpi.com
Cancer represents a group of heterogeneous diseases characterized by uncontrolled
growth and spread of abnormal cells, ultimately leading to death. Nanomedicine plays a …

Spray drying of pharmaceuticals and biopharmaceuticals: Critical parameters and experimental process optimization approaches

A Ziaee, AB Albadarin, L Padrela, T Femmer… - European Journal of …, 2019 - Elsevier
Spray drying is increasingly becoming recognized as an efficient drying and formulation
technique for pharmaceutical and biopharmaceutical processing. It offers significant …

Poly (2-oxazoline) s based biomaterials: A comprehensive and critical update

T Lorson, MM Luebtow, E Wegener, MS Haider… - Biomaterials, 2018 - Elsevier
Abstract Poly (2-oxazoline) s have been investigated for decades as biomaterials.
Pioneering early work suggested that hydrophilic poly (2-oxazoline) s are comparable to …

[HTML][HTML] Pharmaceutical particle technologies: An approach to improve drug solubility, dissolution and bioavailability

P Khadka, J Ro, H Kim, I Kim, JT Kim, H Kim… - Asian journal of …, 2014 - Elsevier
Pharmaceutical particle technology is employed to improve poor aqueous solubility of drug
compounds that limits in vivo bioavailability owing to their low dissolution rate in the …

Controlled drug release from pharmaceutical nanocarriers

JH Lee, Y Yeo - Chemical engineering science, 2015 - Elsevier
Nanocarriers providing spatiotemporal control of drug release contribute to reducing toxicity
and improving therapeutic efficacy of a drug. On the other hand, nanocarriers face unique …

On the biodegradability of polyethylene glycol, polypeptoids and poly (2-oxazoline) s

J Ulbricht, R Jordan, R Luxenhofer - Biomaterials, 2014 - Elsevier
Despite being the gold standard of hydrophilic biomaterials and well known sensitivity of
polyethylene glycol (PEG) against oxidative degradation, very little information on the …

Polymeric micelles of biodegradable diblock copolymers: enhanced encapsulation of hydrophobic drugs

YHA Hussein, M Youssry - Materials, 2018 - mdpi.com
Polymeric micelles are potentially efficient in encapsulating and performing the controlled
release of various hydrophobic drug molecules. Understanding the fundamental …

Nanopreparations to overcome multidrug resistance in cancer

NR Patel, BS Pattni, AH Abouzeid… - Advanced drug delivery …, 2013 - Elsevier
Multidrug resistance is the most widely exploited phenomenon by which cancer eludes
chemotherapy. Broad variety of factors, ranging from the cellular ones, such as over …

Harnessing amphiphilic polymeric micelles for diagnostic and therapeutic applications: Breakthroughs and bottlenecks

J Kaur, V Mishra, SK Singh, M Gulati, B Kapoor… - Journal of Controlled …, 2021 - Elsevier
Amphiphilic block copolymers are widely utilized in the design of formulations owing to their
unique physicochemical properties, flexible structures and functional chemistry. Amphiphilic …