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Polymeric micelles for the delivery of poorly soluble drugs: From nanoformulation to clinical approval
Over the last three decades, polymeric micelles have emerged as a highly promising drug
delivery platform for therapeutic compounds. Particularly, poorly soluble small molecules …
delivery platform for therapeutic compounds. Particularly, poorly soluble small molecules …
Nanoparticle-mediated combination therapy: two-in-one approach for cancer
Cancer represents a group of heterogeneous diseases characterized by uncontrolled
growth and spread of abnormal cells, ultimately leading to death. Nanomedicine plays a …
growth and spread of abnormal cells, ultimately leading to death. Nanomedicine plays a …
Spray drying of pharmaceuticals and biopharmaceuticals: Critical parameters and experimental process optimization approaches
Spray drying is increasingly becoming recognized as an efficient drying and formulation
technique for pharmaceutical and biopharmaceutical processing. It offers significant …
technique for pharmaceutical and biopharmaceutical processing. It offers significant …
Poly (2-oxazoline) s based biomaterials: A comprehensive and critical update
Abstract Poly (2-oxazoline) s have been investigated for decades as biomaterials.
Pioneering early work suggested that hydrophilic poly (2-oxazoline) s are comparable to …
Pioneering early work suggested that hydrophilic poly (2-oxazoline) s are comparable to …
[HTML][HTML] Pharmaceutical particle technologies: An approach to improve drug solubility, dissolution and bioavailability
P Khadka, J Ro, H Kim, I Kim, JT Kim, H Kim… - Asian journal of …, 2014 - Elsevier
Pharmaceutical particle technology is employed to improve poor aqueous solubility of drug
compounds that limits in vivo bioavailability owing to their low dissolution rate in the …
compounds that limits in vivo bioavailability owing to their low dissolution rate in the …
Controlled drug release from pharmaceutical nanocarriers
Nanocarriers providing spatiotemporal control of drug release contribute to reducing toxicity
and improving therapeutic efficacy of a drug. On the other hand, nanocarriers face unique …
and improving therapeutic efficacy of a drug. On the other hand, nanocarriers face unique …
On the biodegradability of polyethylene glycol, polypeptoids and poly (2-oxazoline) s
Despite being the gold standard of hydrophilic biomaterials and well known sensitivity of
polyethylene glycol (PEG) against oxidative degradation, very little information on the …
polyethylene glycol (PEG) against oxidative degradation, very little information on the …
Polymeric micelles of biodegradable diblock copolymers: enhanced encapsulation of hydrophobic drugs
Polymeric micelles are potentially efficient in encapsulating and performing the controlled
release of various hydrophobic drug molecules. Understanding the fundamental …
release of various hydrophobic drug molecules. Understanding the fundamental …
Nanopreparations to overcome multidrug resistance in cancer
Multidrug resistance is the most widely exploited phenomenon by which cancer eludes
chemotherapy. Broad variety of factors, ranging from the cellular ones, such as over …
chemotherapy. Broad variety of factors, ranging from the cellular ones, such as over …
Harnessing amphiphilic polymeric micelles for diagnostic and therapeutic applications: Breakthroughs and bottlenecks
Amphiphilic block copolymers are widely utilized in the design of formulations owing to their
unique physicochemical properties, flexible structures and functional chemistry. Amphiphilic …
unique physicochemical properties, flexible structures and functional chemistry. Amphiphilic …