Cell-substrate interactions play a crucial role in the design of better biomaterials and
integration of implants with the tissues. Adhesion is the binding process of the cells to the …

Conspectus Over the past decade, there has been growing interest in develo**
biosensors and devices with nanoscale and vertical topography. Vertical nanostructures …

Topographical cues on cells can, through contact guidance, alter cellular plasticity and
accelerate the regeneration of cultured tissue. Here we show how changes in the nuclear …

Cells have evolved multiple mechanisms to apprehend and adapt finely to their
environment. Here we report a new cellular ability, which we term “curvotaxis” that enables …

The mechanical stability and deformability of the cell nucleus are crucial to many biological
processes, including migration, proliferation and polarization. In vivo, the cell nucleus is …

Visualization of chromosomal dynamics is important for understanding many fundamental
intra-nuclear processes. Efficient and reliable live-cell multicolor labeling of chromosomal …

Historically the culture of mammalian cells in the laboratory has been performed on planar
substrates with media cocktails that are optimized to maintain phenotype. However, it is …

The physiological microenvironment of the stem cell niche, including the three factors of
stiffness, topography, and dimension, is crucial to stem cell proliferation and differentiation …

While various material factors have been shown to influence cell behaviors, recent studies
started to pay attention to the effects of some material cues on “subcellular” geometry of …

Titanium (Ti) is commonly used in dental implant applications. Surface modification
strategies are being followed in last years in order to build Ti oxide-based surfaces that can …