The potential of metabolomics in biomedical applications

V Gonzalez-Covarrubias, E Martínez-Martínez… - Metabolites, 2022 - mdpi.com
The metabolome offers a dynamic, comprehensive, and precise picture of the phenotype.
Current high-throughput technologies have allowed the discovery of relevant metabolites …

Cardiovascular metabolomics

RW McGarrah, SB Crown, GF Zhang, SH Shah… - Circulation …, 2018 - Am Heart Assoc
Disturbances in cardiac metabolism underlie most cardiovascular diseases. Metabolomics,
one of the newer omics technologies, has emerged as a powerful tool for defining changes …

Chemometrics in metabolomics—a review in human disease diagnosis

R Madsen, T Lundstedt, J Trygg - Analytica chimica acta, 2010 - Elsevier
Metabolomics is a post genomic research field concerned with develo** methods for
analysis of low molecular weight compounds in biological systems, such as cells, organs or …

Systems proteomics of liver mitochondria function

EG Williams, Y Wu, P Jha, S Dubuis, P Blattmann… - Science, 2016 - science.org
INTRODUCTION Over the past two decades, continuous improvements in “omics”
technologies have driven an ever-greater capacity to define the relationships between …

Combined metabolomic and proteomic analysis of human atrial fibrillation

M Mayr, S Yusuf, G Weir, YL Chung, U Mayr… - Journal of the American …, 2008 - jacc.org
Objectives: We sought to decipher metabolic processes servicing the increased energy
demand during persistent atrial fibrillation (AF) and to ascertain whether metabolic …

Diagnosis and monitoring of abdominal aortic aneurysm: current status and future prospects

JV Moxon, A Parr, TI Emeto, P Walker… - Current problems in …, 2010 - Elsevier
Abdominal aortic aneurysm (AAA) remains an important cause of morbidity and mortality in
elderly men, and prevalence is predicted to increase in parallel with a global aging …

Proteomics, metabolomics, and immunomics on microparticles derived from human atherosclerotic plaques

M Mayr, D Grainger, U Mayr, AS Leroyer… - Circulation …, 2009 - Am Heart Assoc
Background—Microparticles (MPs) with procoagulant activity are present in human
atherosclerosis, but no detailed information is available on their composition. Methods and …

Proteomics identifies thymidine phosphorylase as a key regulator of the angiogenic potential of colony-forming units and endothelial progenitor cell cultures

G Pula, U Mayr, C Evans, M Prokopi, DS Vara… - Circulation …, 2009 - Am Heart Assoc
Endothelial progenitor cell (EPC) cultures and colony-forming units (CFUs) have been
extensively studied for their therapeutic and diagnostic potential. Recent data suggest a role …

Proteomics: from single molecules to biological pathways

SR Langley, J Dwyer, I Drozdov, X Yin… - Cardiovascular …, 2013 - academic.oup.com
The conventional reductionist approach to cardiovascular research investigates individual
candidate factors or linear signalling pathways but ignores more complex interactions in …

Single-platform 'multi-omic'profiling: unified mass spectrometry and computational workflows for integrative proteomics–metabolomics analysis

BC Blum, F Mousavi, A Emili - Molecular Omics, 2018 - pubs.rsc.org
The objective of omics studies is to globally measure the different classes of cellular
biomolecules present in a biological specimen (eg proteins, metabolites) as accurately as …