Core-binding factors (CBFs) are a class of haematopoietic transcription factors that are
crucial for the regulation of haematopoietic ontogeny, and are frequent targets of mutation …

Runx2 is essential for osteoblast development and proper bone formation. A member of the
Runt domain family of transcription factors, Runx2 binds specific DNA sequences to regulate …

The highly conserved and ubiquitously expressed 14‐3‐3 proteins regulate differentiation,
cell cycle progression and apoptosis by binding intracellular phosphoproteins involved in …

A protein module called the WW domain recognizes and binds to a short oligopeptide called
the PY motif, PPxY, to mediate protein–protein interactions. The PY motif is present in the …

ABSTRACT Cbfa2 (AML1) encodes the DNA-binding subunit of a transcription factor in the
small family of core-binding factors (CBFs). Cbfa2 is required for the differentiation of all …

Cbfa1 is an essential transcription factor for osteoblast differentiation and bone formation.
We investigated functional differences among three isoforms of Cbfa1: Type I (originally …

Differential display of mRNA was used to identify concordant changes in gene expression
induced by two mood‐stabilizing agents, lithium and valproate (VPA). Both treatments, on …

Familial platelet disorder with predisposition to acute myelogenous leukemia (FPD/AML) is
an autosomal dominant familial platelet disorder characterized by thrombocytopenia and a …

Parathyroid hormone (PTH) is an 84-amino-acid polypeptide hormone functioning as a
major mediator of bone remodeling and as an essential regulator of calcium homeostasis …

A common chromosomal translocation in acute myeloid leukemia (AML) involves the AML1
(acute myeloid leukemia 1, also called RUNX1, core binding factor protein (CBFα), and …