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Neutrophil extracellular traps in homeostasis and disease
H Wang, SJ Kim, Y Lei, S Wang, H Wang… - … and Targeted Therapy, 2024 - nature.com
Neutrophil extracellular traps (NETs), crucial in immune defense mechanisms, are
renowned for their propensity to expel decondensed chromatin embedded with inflammatory …
renowned for their propensity to expel decondensed chromatin embedded with inflammatory …
SARS-CoV-2 immunity in animal models
Z Chen, Y Yuan, Q Hu, A Zhu, F Chen, S Li… - Cellular & Molecular …, 2024 - nature.com
The COVID-19 pandemic, which was caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), has become a worldwide health crisis due to its …
coronavirus 2 (SARS-CoV-2), has become a worldwide health crisis due to its …
NFκB and NLRP3/NLRC4 inflammasomes regulate differentiation, activation and functional properties of monocytes in response to distinct SARS-CoV-2 proteins
I Tsukalov, I Sánchez-Cerrillo, O Rajas… - Nature …, 2024 - nature.com
Increased recruitment of transitional and non-classical monocytes in the lung during SARS-
CoV-2 infection is associated with COVID-19 severity. However, whether specific innate …
CoV-2 infection is associated with COVID-19 severity. However, whether specific innate …
[HTML][HTML] TLRs: innate immune sentries against SARS-CoV-2 infection
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), has been responsible for a devastating pandemic since March …
coronavirus 2 (SARS-CoV-2), has been responsible for a devastating pandemic since March …
The roles of arginases and arginine in immunity
Arginase activity and arginine metabolism in immune cells have important consequences for
health and disease. Their dysregulation is commonly observed in cancer, autoimmune …
health and disease. Their dysregulation is commonly observed in cancer, autoimmune …
Genetically engineered cellular nanovesicle as targeted DNase I delivery system for the clearance of neutrophil extracellular traps in acute lung injury
Y Du, Y Chen, F Li, Z Mao, Y Ding… - Advanced Science, 2023 - Wiley Online Library
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) are prevalent critical
illnesses with a high mortality rate among patients in intensive care units. Neutrophil …
illnesses with a high mortality rate among patients in intensive care units. Neutrophil …
Heparin, low molecular weight heparin, and non-anticoagulant derivatives for the treatment of inflammatory lung disease
JK Shute - Pharmaceuticals, 2023 - mdpi.com
Unfractionated heparin has multiple pharmacological activities beyond anticoagulation.
These anti-inflammatory, anti-microbial, and mucoactive activities are shared in part by low …
These anti-inflammatory, anti-microbial, and mucoactive activities are shared in part by low …
[HTML][HTML] COVID-19 and the concept of thrombo-inflammation: Review of the relationship between immune response, endothelium and coagulation
E de Maistre, P Savard, PG Guinot - Journal of Clinical Medicine, 2023 - mdpi.com
COVID-19, caused by the SARS-CoV-2 virus, has revealed a complex interplay between
inflammation and coagulation, leading to the emergence of the concept of thrombo …
inflammation and coagulation, leading to the emergence of the concept of thrombo …
[HTML][HTML] Ribociclib leverages phosphodiesterase 4 inhibition in the treatment of neutrophilic inflammation and acute respiratory distress syndrome
PJ Chen, SH Chen, YL Chen, YH Wang, CY Lin… - Journal of Advanced …, 2024 - Elsevier
Introduction Overwhelming neutrophil activation and oxidative stress significantly contribute
to acute respiratory distress syndrome (ARDS) pathogenesis. However, the potential of …
to acute respiratory distress syndrome (ARDS) pathogenesis. However, the potential of …
Smoking and va** alter genes related to mechanisms of SARS-CoV-2 susceptibility and severity: a systematic review and meta-analysis
R Bowsher, TH Marczylo, K Gooch… - European …, 2024 - publications.ersnet.org
Background Evidence for the impact of smoking on coronavirus disease 2019 (COVID-19) is
contradictory, and there is little research on va**. Here we provide greater clarity on …
contradictory, and there is little research on va**. Here we provide greater clarity on …