Neutrophil extracellular traps in homeostasis and disease

H Wang, SJ Kim, Y Lei, S Wang, H Wang… - … and Targeted Therapy, 2024 - nature.com
Neutrophil extracellular traps (NETs), crucial in immune defense mechanisms, are
renowned for their propensity to expel decondensed chromatin embedded with inflammatory …

SARS-CoV-2 immunity in animal models

Z Chen, Y Yuan, Q Hu, A Zhu, F Chen, S Li… - Cellular & Molecular …, 2024 - nature.com
The COVID-19 pandemic, which was caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), has become a worldwide health crisis due to its …

NFκB and NLRP3/NLRC4 inflammasomes regulate differentiation, activation and functional properties of monocytes in response to distinct SARS-CoV-2 proteins

I Tsukalov, I Sánchez-Cerrillo, O Rajas… - Nature …, 2024 - nature.com
Increased recruitment of transitional and non-classical monocytes in the lung during SARS-
CoV-2 infection is associated with COVID-19 severity. However, whether specific innate …

[HTML][HTML] TLRs: innate immune sentries against SARS-CoV-2 infection

S Mantovani, B Oliviero, S Varchetta, A Renieri… - International Journal of …, 2023 - mdpi.com
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), has been responsible for a devastating pandemic since March …

The roles of arginases and arginine in immunity

S Canè, R Geiger, V Bronte - Nature Reviews Immunology, 2024 - nature.com
Arginase activity and arginine metabolism in immune cells have important consequences for
health and disease. Their dysregulation is commonly observed in cancer, autoimmune …

Genetically engineered cellular nanovesicle as targeted DNase I delivery system for the clearance of neutrophil extracellular traps in acute lung injury

Y Du, Y Chen, F Li, Z Mao, Y Ding… - Advanced Science, 2023 - Wiley Online Library
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) are prevalent critical
illnesses with a high mortality rate among patients in intensive care units. Neutrophil …

Heparin, low molecular weight heparin, and non-anticoagulant derivatives for the treatment of inflammatory lung disease

JK Shute - Pharmaceuticals, 2023 - mdpi.com
Unfractionated heparin has multiple pharmacological activities beyond anticoagulation.
These anti-inflammatory, anti-microbial, and mucoactive activities are shared in part by low …

[HTML][HTML] COVID-19 and the concept of thrombo-inflammation: Review of the relationship between immune response, endothelium and coagulation

E de Maistre, P Savard, PG Guinot - Journal of Clinical Medicine, 2023 - mdpi.com
COVID-19, caused by the SARS-CoV-2 virus, has revealed a complex interplay between
inflammation and coagulation, leading to the emergence of the concept of thrombo …

[HTML][HTML] Ribociclib leverages phosphodiesterase 4 inhibition in the treatment of neutrophilic inflammation and acute respiratory distress syndrome

PJ Chen, SH Chen, YL Chen, YH Wang, CY Lin… - Journal of Advanced …, 2024 - Elsevier
Introduction Overwhelming neutrophil activation and oxidative stress significantly contribute
to acute respiratory distress syndrome (ARDS) pathogenesis. However, the potential of …

Smoking and va** alter genes related to mechanisms of SARS-CoV-2 susceptibility and severity: a systematic review and meta-analysis

R Bowsher, TH Marczylo, K Gooch… - European …, 2024 - publications.ersnet.org
Background Evidence for the impact of smoking on coronavirus disease 2019 (COVID-19) is
contradictory, and there is little research on va**. Here we provide greater clarity on …