The placenta in preeclampsia

JM Roberts, C Escudero - Pregnancy Hypertension: An International …, 2012 - Elsevier
The root cause of preeclampsia is the placenta. Preeclampsia begins to abate with the
delivery of the placenta and can occur in the absence of a fetus but with the presence of …

Omics of blood pressure and hypertension

DK Arnett, SA Claas - Circulation Research, 2018 - Am Heart Assoc
Essential hypertension is a common, complex disorder affecting≤ 1 billion adults globally.
Blood pressure is a highly heritable trait, with≤ 50% of the variation between individuals …

Genetic risk factors associated with preeclampsia and hypertensive disorders of pregnancy

JS Tyrmi, T Kaartokallio, AI Lokki… - JAMA …, 2023 - jamanetwork.com
Importance A genetic contribution to preeclampsia susceptibility has been established but is
still incompletely understood. Objective To disentangle the underlying genetic architecture of …

Protein misfolding, congophilia, oligomerization, and defective amyloid processing in preeclampsia

IA Buhimschi, UA Nayeri, G Zhao, LL Shook… - Science translational …, 2014 - science.org
Preeclampsia is a pregnancy-specific disorder of unknown etiology and a leading
contributor to maternal and perinatal morbidity and mortality worldwide. Because there is no …

A review of omics approaches to study preeclampsia

PA Benny, FM Alakwaa, RJ Schlueter, CB Lassiter… - Placenta, 2020 - Elsevier
Preeclampsia is a medical condition affecting 5–10% of pregnancies. It has serious effects
on the health of the pregnant mother and develo** fetus. While possible causes of …

Urinary proteomics for prediction of preeclampsia

DM Carty, J Siwy, JE Brennand, P Zürbig, W Mullen… - …, 2011 - Am Heart Assoc
Preeclampsia is a major determinant of fetal and maternal morbidity and mortality. We used
a proteomic strategy to identify urinary biomarkers that predict preeclampsia before the …

Protein misfolding during pregnancy: new approaches to preeclampsia diagnostics

EM Gerasimova, SA Fedotov, DV Kachkin… - International journal of …, 2019 - mdpi.com
Preeclampsia (PE) is a multisystem heterogeneous complication of pregnancy remaining a
leading cause of maternal and perinatal morbidity and mortality over the world. PE has a …

Human pregnancy zone protein stabilizes misfolded proteins including preeclampsia-and Alzheimer's-associated amyloid beta peptide

JH Cater, JR Kumita… - Proceedings of the …, 2019 - National Acad Sciences
Protein misfolding underlies the pathology of a large number of human disorders, many of
which are age-related. An exception to this is preeclampsia, a leading cause of pregnancy …

[HTML][HTML] Albumin: Source, preparation, determination, applications, and prospects

TPH Hutapea, KA Madurani, MY Syahputra… - Journal of Science …, 2023 - Elsevier
Albumin is a water-soluble protein that has attracted attention due to its characteristics,
including biocompatibility, biodegradability, non-immunogenicity, long half-life, minimal …

Urinary protein and peptide markers in chronic kidney disease

N Chebotareva, A Vinogradov, V McDonnell… - International journal of …, 2021 - mdpi.com
Chronic kidney disease (CKD) is a non-specific type of kidney disease that causes a gradual
decline in kidney function (from months to years). CKD is a significant risk factor for death …