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Functional and biomimetic materials for engineering of the three-dimensional cell microenvironment
The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …
Intervertebral disc degeneration: biomaterials and tissue engineering strategies toward precision medicine
Intervertebral disc degeneration is a common cause of discogenic low back pain resulting in
significant disability. Current conservative or surgical intervention treatments do not reverse …
significant disability. Current conservative or surgical intervention treatments do not reverse …
Biomaterials for intervertebral disc regeneration and repair
The intervertebral disc contributes to motion, weight bearing, and flexibility of the spine, but
is susceptible to damage and morphological changes that contribute to pathology with age …
is susceptible to damage and morphological changes that contribute to pathology with age …
Development of a nanohybrid peptide hydrogel for enhanced intervertebral disc repair and regeneration
Effective therapeutic approaches to overcome the heterogeneous pro-inflammatory and
inhibitory extracellular matrix (ECM) microenvironment are urgently needed to achieve …
inhibitory extracellular matrix (ECM) microenvironment are urgently needed to achieve …
Electrospun nanofibers for regenerative medicine
Abstract This Progress Report reviews recent progress in applying electrospun nanofibers to
the emerging field of regenerative medicine. It begins with a brief introduction to …
the emerging field of regenerative medicine. It begins with a brief introduction to …
Method for picrosirius red-polarization detection of collagen fibers in tissue sections
The extracellular matrix is critical in guiding cell behavior in normal and pathologic tissues,
particularly in cancers and fibrosis. Highlighting the organization (or disorganization) of a …
particularly in cancers and fibrosis. Highlighting the organization (or disorganization) of a …
Cytoskeletal to nuclear strain transfer regulates YAP signaling in mesenchymal stem cells
Mechanical forces transduced to cells through the extracellular matrix are critical regulators
of tissue development, growth, and homeostasis, and can play important roles in directing …
of tissue development, growth, and homeostasis, and can play important roles in directing …
Degeneration and regeneration of the intervertebral disc: lessons from development
Degeneration of the intervertebral discs, a process characterized by a cascade of cellular,
biochemical, structural and functional changes, is strongly implicated as a cause of low back …
biochemical, structural and functional changes, is strongly implicated as a cause of low back …
[HTML][HTML] Topography: a biophysical approach to direct the fate of mesenchymal stem cells in tissue engineering applications
Tissue engineering is a promising strategy to treat tissue and organ loss or damage caused
by injury or disease. During the past two decades, mesenchymal stem cells (MSCs) have …
by injury or disease. During the past two decades, mesenchymal stem cells (MSCs) have …
Role of biomechanics in intervertebral disc degeneration and regenerative therapies: what needs repairing in the disc and what are promising biomaterials for its …
BACKGROUND CONTEXT: Degeneration and injuries of the intervertebral disc (IVD) result
in large alterations in biomechanical behaviors. Repair strategies using biomaterials can be …
in large alterations in biomechanical behaviors. Repair strategies using biomaterials can be …