During oncogenesis, cells become unrestrictedly proliferative thereby altering the tissue
homeostasis and resulting in subsequent hyperplasia. This process is paralleled by …

The p53 tumor suppressor continues to hold distinction as the most frequently mutated gene
in human cancer. The ability of p53 to induce programmed cell death, or apoptosis, of cells …

The p53-related genes p63 and p73 exhibit significant structural homology to p53; however,
they do not function as classical tumor suppressors and are rarely mutated in human …

Abstract p53 and its related genes, p63 and p73 constitute the p53 gene family. While p53 is
the most frequently mutated gene in human tumors, p63 and p73 are rarely mutated or …

This multicenter study assesses the value of O 6-methylguanine-DNA methyltransferase
(MGMT) status for predicting overall survival in glioblastoma patients. Five methods are …

TP53, TP63, and TP73 genes comprise the p53 family. Each gene produces protein
isoforms through multiple mechanisms including extensive alternative mRNA splicing …

Background To analyze the functional and oncological results after re-operation for recurrent
WHO grade II Glioma located in eloquent regions. Method We reviewed a consecutive …

BACKGROUND & AIMS: Inactivation of the product of the tumor suppressor gene TP73 does
not usually occur by mutation but rather through expression of truncated isoforms that have …

The p53 tumor suppressor is part of a small family of related proteins that includes two other
members, p73 and p63. Interest in the p53 family members, their functions and their complex …

Glioblastoma Multiforme is one of the most highly metastatic cancers and constitutes 70% of
all gliomas. Despite aggressive treatments these tumours have an exceptionally bad …