Wnt signaling is a highly conserved signaling pathway that plays a critical role in controlling
embryonic and organ development, as well as cancer progression. Genome-wide …

As the most commonly occurring cancer in women worldwide, breast cancer poses a
formidable public health challenge on a global scale. Breast cancer consists of a group of …

Wnt signaling is one of the key cascades regulating development and stemness, and has
also been tightly associated with cancer. The role of Wnt signaling in carcinogenesis has …

Proliferation is an important part of cancer development and progression. This is manifest by
altered expression and/or activity of cell cycle related proteins. Constitutive activation of …

Since the initial discovery of the oncogenic activity of WNT1 in mouse mammary glands, our
appreciation for the complex roles for WNT signalling pathways in cancer has increased …

Breast cancer is the most common form of cancer diagnosed in women worldwide and the
second leading cause of cancer-related deaths in the USA. Despite the development of …

The Dishevelled gene was first identified in Drosophila mutants with disoriented hair and
bristle polarity [[1],[2],[3]]. The Dsh gene (Dsh/Dvl, in Drosophila and vertebrates …

Cancer genome sequencing studies indicate that a single breast cancer typically harbours
multiple genetically distinct subclones,,,. As carcinogenesis involves a breakdown in the cell …

The canonical Wnt cascade has emerged as a critical regulator of stem cells. In many
tissues, activation of Wnt signalling has also been associated with cancer. This has raised …

The existence of mammary stem cells (MaSCs) has been postulated from evidence that the
mammary gland can be regenerated by transplantation of epithelial fragments in mice …