The efficacy of Roux-en-Y gastric-bypass (RYGB) and other bariatric surgeries in the
management of obesity and type 2 diabetes mellitus and novel developments in …

Background The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the
endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence …

Analysis of human pathology led Braak to postulate that α-synuclein (α-syn) pathology could
spread from the gut to brain via the vagus nerve. Here, we test this postulate by assessing α …

The gut-brain axis, which is mediated via enteric and central neurohormonal signaling, is
known to regulate a broad set of physiological functions from feeding to emotional behavior …

Obesity is reaching epidemic proportions globally and represents a major cause of
comorbidities, mostly related to cardiovascular disease. The autonomic nervous system …

Small synthetic molecules called growth hormone secretagogues (GHSs) stimulate the
release of growth hormone (GH) from the pituitary. They act through the GHS-R, a G protein …

Ghrelin is a hormone that stimulates growth hormone secretion and signals energy
insufficiency via interaction with its receptor, the growth hormone secretagogue receptor …

The CNS regulates body weight; however, we still lack a clear understanding of what drives
decisions about when, how much and what to eat. A vast array of peripheral signals …

The molecular mechanisms regulating secretion of the orexigenic-glucoregulatory hormone
ghrelin remain unclear. Based on qPCR analysis of FACS-purified gastric ghrelin cells …

Ghrelin, an acylated upper gastrointestinal peptide, is the only known orexigenic hormone.
Considerable evidence implicates ghrelin in mealtime hunger and meal initiation …