Top-down analysis of intact proteins and middle-down analysis of proteins subjected to
limited digestion require efficient detection of traces of proteoforms in samples, necessitating …

In today's post-genomic era, it is crucial to rethink the concept of model organisms. While a
few historically well-established organisms, eg laboratory rodents, have enabled significant …

The misfolding and aggregation of α-synuclein is linked to a family of neurodegenerative
disorders known as synucleinopathies, the most prominent of which is Parkinson's disease …

Voluntary striated muscles are characterized by a highly complex and dynamic proteome
that efficiently adapts to changed physiological demands or alters considerably during …

Alternative splicing is a major contributor of transcriptomic complexity, but the extent to which
transcript isoforms are translated into stable, functional protein isoforms is unclear …

Soil microbiome characterization is typically achieved with next-generation sequencing
(NGS) techniques. Metabarcoding is very common, and meta-omics is growing in popularity …

The long-read RNA sequencing developed by Oxford Nanopore Technology provides a
direct quantification of transcript isoforms. That makes the number of transcript isoforms per …

Precise prefractionation of proteome samples is a potent method for realizing in-depth
analysis in top-down proteomics. PEPPI-MS (Passively Eluting Proteins from Polyacrylamide …

ABSTRACT The International Rare Diseases Research Consortium (IRDiRC) Diagnostic
Scientific Committee (DSC) is charged with discussion and contribution to progress on …

Citrus huanglongbing (HLB) is a major challenge that impacts the flourishing of the citrus
industry. Therefore, analyzing the genomic information of HLB-resistant or tolerant citrus …