TRP channels as cellular sensors
DE Clapham - Nature, 2003 - nature.com
TRP channels are the vanguard of our sensory systems, responding to temperature, touch,
pain, osmolarity, pheromones, taste and other stimuli. But their role is much broader than …
pain, osmolarity, pheromones, taste and other stimuli. But their role is much broader than …
Autosomal dominant polycystic kidney disease
VE Torres, PC Harris, Y Pirson - The Lancet, 2007 - thelancet.com
Autosomal dominant polycystic kidney disease is the most prevalent, potentially lethal,
monogenic disorder. It is associated with large interfamilial and intrafamilial variability, which …
monogenic disorder. It is associated with large interfamilial and intrafamilial variability, which …
Structure of the human PKD1-PKD2 complex
Q Su, F Hu, X Ge, J Lei, S Yu, T Wang, Q Zhou, C Mei… - Science, 2018 - science.org
INTRODUCTION Mutations in two genes, PKD1 and PKD2, are responsible for about 85 and
10% of all cases of autosomal dominant polycystic kidney disease (ADPKD), one of the most …
10% of all cases of autosomal dominant polycystic kidney disease (ADPKD), one of the most …
Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells
Several proteins implicated in the pathogenesis of polycystic kidney disease (PKD) localize
to cilia. Furthermore, cilia are malformed in mice with PKD with mutations in TgN737Rpw …
to cilia. Furthermore, cilia are malformed in mice with PKD with mutations in TgN737Rpw …
The structure of the polycystic kidney disease channel PKD2 in lipid nanodiscs
Summary The Polycystic Kidney Disease 2 (Pkd2) gene is mutated in autosomal dominant
polycystic kidney disease (ADPKD), one of the most common human monogenic disorders …
polycystic kidney disease (ADPKD), one of the most common human monogenic disorders …
An introduction to TRP channels
▪ Abstract The aim of this review is to provide a basic framework for understanding the
function of mammalian transient receptor potential (TRP) channels, particularly as they have …
function of mammalian transient receptor potential (TRP) channels, particularly as they have …
Transient receptor potential cation channels in disease
The transient receptor potential (TRP) superfamily consists of a large number of cation
channels that are mostly permeable to both monovalent and divalent cations. The 28 …
channels that are mostly permeable to both monovalent and divalent cations. The 28 …
Autosomal dominant polycystic kidney disease
PA Gabow - New England Journal of Medicine, 1993 - Mass Medical Soc
Autosomal dominant polycystic kidney disease is one of the most common hereditary
disorders, being 10 times more common than sickle cell disease, 15 times more common …
disorders, being 10 times more common than sickle cell disease, 15 times more common …
The primary cilium as the cell's antenna: signaling at a sensory organelle
V Singla, JF Reiter - science, 2006 - science.org
Almost every vertebrate cell has a specialized cell surface projection called a primary cilium.
Although these structures were first described more than a century ago, the full scope of their …
Although these structures were first described more than a century ago, the full scope of their …
Functional polycystin-1 dosage governs autosomal dominant polycystic kidney disease severity
Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations to PKD1 or
PKD2, triggering progressive cystogenesis and typically leading to end-stage renal disease …
PKD2, triggering progressive cystogenesis and typically leading to end-stage renal disease …