In this contribution, we provide a comprehensive overview of acyclic twisted amides,
covering the literature since 1993 (the year of the first recognized report on acyclic twisted …

The concept of using amide bond distortion to modulate amidic resonance has been known
for more than 75 years. Two classic twisted amides (bridged lactams) ingeniously designed …

We report an organocatalyst that combines a triazolium N-heterocyclic carbene (NHC) with a
squaramide as a hydrogen-bonding donor (HBD), which can effectively catalyze the …

The amide bond is one of the most important functional groups in chemistry and biology. 1
Due to the strong resonance interaction between nN and π* C O orbitals (Figure 1), 2 the …

The solids choline chloride and urea, mixed in a 1: 2 molar proportion, form the iconic deep
eutectic solvent “Reline”. A combination of computational and vibrational spectroscopy tools …

Since the seminal studies by Pauling in 1930s, planarity has become the defining
characteristic of the amide bond. Planarity of amides has central implications for the …

Complete basis set calculations (CBS-QB3) were used to compute the CN rotation barriers
for acetamide and eight related compounds, including acetamide enolate and O-protonated …

The amide bond N− C activation represents a powerful strategy in organic synthesis to
functionalize the historically inert amide linkage. This personal account highlights recent …

In the past several years, tremendous advances have been made in non-classical routes for
amide bond formation that involve transamidation and amidation reactions of activated …

Amide N–C (O) bonds are generally unreactive in cross-coupling reactions employing low-
valent transition metals due to nN→ π* C O resonance. Herein we demonstrate that N-acyl …