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Ferroptosis and necroptosis in the kidney
In the last decade, the role of apoptosis in the pathophysiology of acute kidney injury (AKI)
and AKI to chronic kidney disease (CKD) progression has been revisited as our …
and AKI to chronic kidney disease (CKD) progression has been revisited as our …
Molecular mechanism of diabetic neuropathy and its pharmacotherapeutic targets
Diabetic neuropathy is regarded as one of the most debilitating outcomes of diabetes
mellitus and may cause pain, decreased motility, and even amputation. Diabetic neuropathy …
mellitus and may cause pain, decreased motility, and even amputation. Diabetic neuropathy …
A long noncoding RNA protects the heart from pathological hypertrophy
The role of long noncoding RNA (lncRNA) in adult hearts is unknown; also unclear is how
lncRNA modulates nucleosome remodelling. An estimated 70% of mouse genes undergo …
lncRNA modulates nucleosome remodelling. An estimated 70% of mouse genes undergo …
Regulated cell death and inflammation: an auto-amplification loop causes organ failure
Regulated cell death (RCD) is either immunologically silent or immunogenic. RCD in
parenchymal cells may lead to the release of damage-associated molecular patterns that …
parenchymal cells may lead to the release of damage-associated molecular patterns that …
The therapeutic potential of poly (ADP-ribose) polymerase inhibitors
Abstract Poly (ADP-ribose) polymerase-1 (PARP-1) is a member of the PARP enzyme family
consisting of PARP-1 and several recently identified novel poly (ADP-ribosylating) enzymes …
consisting of PARP-1 and several recently identified novel poly (ADP-ribosylating) enzymes …
Therapeutic applications of PARP inhibitors: anticancer therapy and beyond
The aim of this article is to describe the current and potential clinical translation of
pharmacological inhibitors of poly (ADP-ribose) polymerase (PARP) for the therapy of …
pharmacological inhibitors of poly (ADP-ribose) polymerase (PARP) for the therapy of …
Poly (ADP-ribose) polymerase and the therapeutic effects of its inhibitors
Abstract Poly (ADP-ribose) polymerases (PARPs) are involved in the regulation of many
cellular functions. Three consequences of the activation of PARP1, which is the main isoform …
cellular functions. Three consequences of the activation of PARP1, which is the main isoform …
Chromatin regulation by Brg1 underlies heart muscle development and disease
Cardiac hypertrophy and failure are characterized by transcriptional reprogramming of gene
expression. Adult cardiomyocytes in mice primarily express α-myosin heavy chain (α-MHC …
expression. Adult cardiomyocytes in mice primarily express α-myosin heavy chain (α-MHC …
Role of poly (ADP‐ribose) polymerase 1 (PARP‐1) in cardiovascular diseases: the therapeutic potential of PARP inhibitors
Accumulating evidence suggests that the reactive oxygen and nitrogen species are
generated in cardiomyocytes and endothelial cells during myocardial ischemia/reperfusion …
generated in cardiomyocytes and endothelial cells during myocardial ischemia/reperfusion …
Renal parenchymal hypoxia, hypoxia adaptation, and the pathogenesis of radiocontrast nephropathy
SN Heyman, S Rosen… - Clinical Journal of the …, 2008 - journals.lww.com
Renal Parenchymal Hypoxia, Hypoxia Adaptation, and the Patho... : Clinical Journal of the
American Society of Nephrology Renal Parenchymal Hypoxia, Hypoxia Adaptation, and the …
American Society of Nephrology Renal Parenchymal Hypoxia, Hypoxia Adaptation, and the …