Nature's chemical signatures in human olfaction: a foodborne perspective for future biotechnology

A Dunkel, M Steinhaus, M Kotthoff… - Angewandte Chemie …, 2014 - Wiley Online Library
The biocatalytic production of flavor naturals that determine chemosensory percepts of foods
and beverages is an ever challenging target for academic and industrial research. Advances …

The olfactory system as marker of neurodegeneration in aging, neurological and neuropsychiatric disorders

N Bhatia-Dey, T Heinbockel - … of environmental research and public health, 2021 - mdpi.com
Research studies that focus on understanding the onset of neurodegenerative pathology
and therapeutic interventions to inhibit its causative factors, have shown a crucial role of …

The missense of smell: functional variability in the human odorant receptor repertoire

JD Mainland, A Keller, YR Li, T Zhou, C Trimmer… - Nature …, 2014 - nature.com
Humans have∼ 400 intact odorant receptors, but each individual has a unique set of
genetic variations that lead to variation in olfactory perception. We used a heterologous …

Genetic variation across the human olfactory receptor repertoire alters odor perception

C Trimmer, A Keller, NR Murphy… - Proceedings of the …, 2019 - National Acad Sciences
Humans use a family of more than 400 olfactory receptors (ORs) to detect odors, but there is
currently no model that can predict olfactory perception from receptor activity patterns …

Sixteen diverse laboratory mouse reference genomes define strain-specific haplotypes and novel functional loci

J Lilue, AG Doran, IT Fiddes, M Abrudan, J Armstrong… - Nature …, 2018 - nature.com
We report full-length draft de novo genome assemblies for 16 widely used inbred mouse
strains and find extensive strain-specific haplotype variation. We identify and characterize …

Olfactory perception of chemically diverse molecules

A Keller, LB Vosshall - BMC neuroscience, 2016 - Springer
Background Understanding the relationship between a stimulus and how it is perceived
reveals fundamental principles about the mechanisms of sensory perception. While this …

On 'electronic nose'methodology

P Boeker - Sensors and Actuators B: Chemical, 2014 - Elsevier
Gas measurement systems used with a particular methodology are sometimes referred to as
“Electronic noses”. Traditionally, these systems were based on unspecific gas sensors as …

A Mendelian trait for olfactory sensitivity affects odor experience and food selection

SR Jaeger, JF McRae, CM Bava, MK Beresford… - Current Biology, 2013 - cell.com
Humans vary in acuity to many odors [1–4], with variation within olfactory receptor (OR)
genes contributing to these differences [5–9]. How such variation also affects odor …

Class I odorant receptors, TAS1R and TAS2R taste receptors, are markers for subpopulations of circulating leukocytes

A Malki, J Fiedler, K Fricke, I Ballweg… - Journal of Leucocyte …, 2015 - academic.oup.com
Our cellular immune system has to cope constantly with foodborne substances that enter the
bloodstream postprandially. Here, they may activate leukocytes via specific but yet mostly …

Profiling of olfactory receptor gene expression in whole human olfactory mucosa

C Verbeurgt, F Wilkin, M Tarabichi, F Gregoire… - PloS one, 2014 - journals.plos.org
Olfactory perception is mediated by a large array of olfactory receptor genes. The human
genome contains 851 olfactory receptor gene loci. More than 50% of the loci are annotated …