Innate immunological pathways in COVID-19 pathogenesis
Coronavirus disease 2019 (COVID-19) is a disease characterized by a profound
dysregulation of the innate immune system. This knowledge has emerged from the large …
dysregulation of the innate immune system. This knowledge has emerged from the large …
Efficacy of antiviral therapies for COVID-19: a systematic review of randomized controlled trials
CTR Vegivinti, KW Evanson, H Lyons, I Akosman… - BMC Infectious …, 2022 - Springer
Abstract Background Coronavirus disease 2019 (COVID-19) continues to pose a significant
threat to public health worldwide. The purpose of this study was to review current evidence …
threat to public health worldwide. The purpose of this study was to review current evidence …
[HTML][HTML] ESCMID COVID-19 living guidelines: drug treatment and clinical management
M Bartoletti, O Azap, A Barac, L Bussini… - Clinical microbiology …, 2022 - Elsevier
Abstract Scope In January 2021, the ESCMID Executive Committee decided to launch a new
initiative to develop ESCMID guidelines on several COVID-19-related issues, including …
initiative to develop ESCMID guidelines on several COVID-19-related issues, including …
[HTML][HTML] Management of hospitalised adults with coronavirus disease 2019 (COVID-19): a European Respiratory Society living guideline
JD Chalmers, ML Crichton… - European respiratory …, 2021 - Eur Respiratory Soc
Introduction Hospitalised patients with coronavirus disease 2019 (COVID-19) as a result of
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have a high …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have a high …
[HTML][HTML] The role of SARS-CoV-2 accessory proteins in immune evasion
Many questions on the SARS-CoV-2 pathogenesis remain to answer. The SARS-CoV-2
genome encodes some accessory proteins that are essential for infection. Notably …
genome encodes some accessory proteins that are essential for infection. Notably …
Antibodies against type I interferon: detection and association with severe clinical outcome in COVID‐19 patients
D Goncalves, M Mezidi, P Bastard… - Clinical & …, 2021 - Wiley Online Library
Objectives Impairment of type I interferon (IFN‐I) immunity has been reported in critically ill
COVID‐19 patients. This defect can be explained in a subset of patients by the presence of …
COVID‐19 patients. This defect can be explained in a subset of patients by the presence of …
Upregulated type I interferon responses in asymptomatic COVID-19 infection are associated with improved clinical outcome
KI Masood, M Yameen, J Ashraf, S Shahid… - Scientific reports, 2021 - nature.com
Understanding key host protective mechanisms against SARS-CoV-2 infection can help
improve treatment modalities for COVID-19. We used a blood transcriptome approach to …
improve treatment modalities for COVID-19. We used a blood transcriptome approach to …
An update of anti-viral treatment of COVID-19.
S ŞİMŞEK YAVUZ… - Turkish journal of …, 2021 - search.ebscohost.com
Background/aim: Currently there is not an effective antiviral treatment for COVID-19, but a
large number of drugs have been evaluated since the beginning of the pandemic, and many …
large number of drugs have been evaluated since the beginning of the pandemic, and many …
Differential roles of interferons in innate responses to mucosal viral infections
Interferons (IFNs) are among the first vertebrate immune pathways activated upon viral
infection and are crucial for control of viral replication and dissemination, especially at …
infection and are crucial for control of viral replication and dissemination, especially at …
Update June 2022: management of hospitalised adults with coronavirus disease 2019 (COVID-19): a European Respiratory Society living guideline
N Roche, ML Crichton, PC Goeminne… - European respiratory …, 2022 - Eur Respiratory Soc
Since the identification of SARS-CoV-2 at the end of 2019, the coronavirus disease 2019
(COVID-19) pandemic has affected more than 410 million people worldwide and killed …
(COVID-19) pandemic has affected more than 410 million people worldwide and killed …