The ruthenium-catalyzed azide alkyne cycloaddition (RuAAC) affords 1, 5-disubstituted 1, 2,
3-triazoles in one step and complements the more established copper-catalyzed reaction …

The last years have seen a steady increase in our understanding of legumain biology that is
driven from two largely uncoupled research arenas, the mammalian and the plant legumain …

Several members of the Rubiaceae and Violaceae families produce a series of cyclotides or
macrocyclic peptides of 29–31 amino acids with an embedded cystine knot. We aim to …

Proteases, though essentially indispensable to the maintenance and survival of their host
organisms, can be potentially damaging when overexpressed or present in higher …

Cyclic peptides are promising scaffolds for drug development, attributable in part to their
increased conformational order compared to linear peptides. However, when optimizing the …

We define plant cyclopeptides [with the exception of the acyclic compounds lasiodine-A (1),
13 sanjoinine-G2 (2), 74 astin-J (216), 156 asternin-AC (217-219), 157 and MCoTI-III (462) …

Plants are known to have many secondary metabolites and phytochemical compounds
which are highly explored at biochemical and molecular genetics level and exploited …

CyBase was originally developed as a database for backbone-cyclized proteins, providing
search and display capabilities for sequence, structure and function data. Cyclic proteins are …

Covering: up to July 2008 Ribosomally synthesized bacterial natural products rival the
nonribosomal peptides in their structural and functional diversity. The last decade has seen …

Serine proteases and their natural protein inhibitors are among the most intensively studied
protein complexes. About 20 structurally diverse inhibitor families have been identified …