During mouse preimplantation embryo development, totipotent blastomeres generate the
first three cell lineages of the embryo: trophectoderm, epiblast and primitive endoderm. In …

Mammalian preimplantation development, which is the period extending from fertilization to
implantation, results in the formation of a blastocyst with three distinct cell lineages. Only one …

Early embryogenesis is a conserved and self-organized process. In the mammalian embryo,
the potential for self-organization is manifested in its extraordinary developmental plasticity …

MicroRNAs (miRNAs) are small non-coding single-stranded RNAs that are integral to a wide
range of cellular processes mainly through the regulation of translation and mRNA stability …

Cells of the inner cell mass (ICM) of the mouse blastocyst differentiate into the pluripotent
epiblast or the primitive endoderm (PrE), marked by the transcription factors NANOG and …

Publisher Summary This chapter focuses on the role of the intracellular cytoskeleton (CSK)
in cell shape determination and tissue morphogenesis. The role of mechanical changes in …

The segregation of the trophectoderm (TE) from the inner cell mass (ICM) in the mouse
blastocyst is determined by position-dependent Hippo signaling. However, the window of …

Compaction of the preimplantation embryo is the earliest morphogenetic process essential
for mammalian development, yet it remains unclear how round cells elongate to form a …

The mouse and human embryo gradually loses totipotency before diversifying into the inner
cell mass (ICM, future organism) and trophectoderm (TE, future placenta). The transcription …

INTRODUCTION During preimplantation development, the establishment of apicobasal cell
polarity is key for the transition from totipotency to pluripotency, which induces cell …