Chronic, excessive neuroinflammation is a key feature of neurodegenerative diseases such
as Alzheimer's disease (AD) and Parkinson's disease (PD). However, neuroinflammatory …

To match the metabolic demands of the brain, mechanisms have evolved to couple neuronal
activity to vasodilation, thus increasing local cerebral blood flow and delivery of oxygen and …

Retinal ganglion cells, the neurons that die in glaucoma, are endowed with a high
metabolism requiring optimal provision of oxygen and nutrients to sustain their activity. The …

White matter microvascular alterations in temporal lobe epilepsy (TLE) may be relevant to
acquired neurodegenerative processes and cognitive impairments associated with this …

Neurovascular unit (NVU) inflammation via activation of glial cells and neuronal damage
plays a critical role in neurodegenerative diseases. Though the exact mechanism of disease …

Abstract 3D bioprinting technology is widely used to fabricate various tissue structures.
However, the absence of vessels hampers the ability of bioprinted tissues to receive oxygen …

Cerebral blood flow (CBF) is important for the maintenance of brain function and its
dysregulation has been implicated in Alzheimer's disease (AD). Microglia associations with …

Pericytes play an indispensable role in various organs and biological processes, such as
promoting angiogenesis, regulating microvascular blood flow, and participating in immune …

This review focuses on the cell adhesion molecule (CAM), known as neural (N)-cadherin
(CDH2). The molecular basis of N-cadherin-mediated intercellular adhesion is discussed, as …

It has been known for some time that Carbonic Anhydrase (CA, EC 4.2. 1.1) plays a complex
role in vascular function, and in the regulation of vascular tone. Clinically employed CA …