The human genome encodes 40 voltage-gated K+ channels (KV), which are involved in
diverse physiological processes ranging from repolarization of neuronal and cardiac action …

Chronic pain is associated with abnormal excitability of the somatosensory system and
remains poorly treated in the clinic. Potassium (K+) channels are crucial determinants of …

KCNQ genes encode five Kv7 K+ channel subunits (Kv7. 1–Kv7. 5). Four of these (Kv7. 2–
Kv7. 5) are expressed in the nervous system. Kv7. 2 and Kv7. 3 are the principal molecular …

This review attempts to give a concise and up-to-date overview on the role of potassium
channels in epilepsies. Their role can be defined from a genetic perspective, focusing on …

Over the past several decades a large amount of data have established that glial cells, the
main cell population in the brain, dynamically interact with neurons and thus impact their …

Simple Summary Diclofenac is a widely used drug for its anti-inflammatory and pain
alleviating properties. This review summarizes the current understanding about the drug …

Potassium channels are tetrameric membrane proteins that selectively conduct K+ across
cellular membranes. With 78 family members, K+ channels make up about half of the …

Gap junctions play an important role in brain physiology. They synchronize neuronal activity
and connect glial cells participating in the regulation of brain metabolism and homeostasis …

Because ion channels are involved in many cellular processes, drugs acting on ion
channels have long been used for the treatment of many diseases, especially those affecting …

Electrical excitation of peripheral somatosensory nerves is a first step in generation of most
pain signals in mammalian nervous system. Such excitation is controlled by an intricate set …