BACKGROUND Antimicrobial peptides (AMPs) are small proteins with potent antibacterial,
antiviral, and antifungal activity. AMPs are ubiquitous among multicellular eukaryotes, with …

Commensal bacteria inhabit mucosal and epidermal surfaces in mice and humans, and
have effects on metabolic and immune pathways in their hosts. Recent studies indicate that …

The human gut microbiome encodes a large variety of antimicrobial peptides (AMPs), but
the short lengths of AMPs pose a challenge for computational prediction. Here we combined …

The amyloid-β peptide (Aβ) is a key protein in Alzheimer's disease (AD) pathology. We
previously reported in vitro evidence suggesting that Aβ is an antimicrobial peptide. We …

Amyloid-β peptide (Aβ) fibrilization and deposition as β-amyloid are hallmarks of Alzheimer's
disease (AD) pathology. We recently reported Aβ is an innate immune protein that protects …

Mucins—large, highly glycosylated proteins—are important for the luminal protection of the
gastrointestinal tract. Enterocytes have their apical surface covered by transmembrane …

The intestinal tract is inhabited by a tremendous number of microorganisms, termed the gut
microbiota. These microorganisms live in a mutualistic relationship with their host and assist …

Microorganisms colonize various ecological niches in the human habitat, as they do in
nature. Predominant forms of multicellular communities called biofilms colonize human …

The intestinal epithelium can be easily disrupted during gut inflammation as seen in
inflammatory bowel disease (IBD), such as ulcerative colitis or Crohn's disease. For a long …

Objective We explore here a novel model for amyloidogenesis in Alzheimer's disease (AD).
This new perspective on AD amyloidosis seeks to provide a rational framework for …