Although oxidants clearly possess the capacity to behave in a random and destructive
fashion, growing evidence suggests that in many instances the production of reactive …

Despite the capacity of chaperones and other homeostatic components to restore folding
equilibrium, cells appear poorly adapted for chronic oxidative stress that increases in cancer …

Carbon monoxide (CO) is generated in living organisms during the degradation of heme by
the enzyme heme oxygenase, which exists in constitutive (HO-2 and HO-3) and inducible …

Curcumin, a widely used spice and coloring agent in food, has been shown to possess
potent antioxidant, antitumor promoting and anti-inflammatory properties in vitro and in vivo …

The discovery of the gaseous molecule nitric oxide in 1987 unraveled investigations on its
functional role in the pathogenesis of a wide spectrum of biological and pathological …

Heat shock proteins (Hsps) have been studied for many years and there is now a large body
of evidence that demonstrates the role of Hsp upregulation in tissue and cell protection in a …

Modulation of endogenous cellular defense mechanisms represents an innovative approach
to therapeutic intervention in diseases causing chronic tissue damage, such as in …

Oxygen has had extraordinary effects on life. Three hundred million years ago, in
Carboniferous times, dragonflies grew as big as seagulls, with wingspans ofnearly a metre …

Carbon monoxide (CO), a gaseous second messenger, arises in biological systems during
the oxidative catabolism of heme by the heme oxygenase (HO) enzymes. HO exists as …

There is significant evidence that the pathogenesis of several neurodegenerative diseases,
including Parkinson's disease, Alzheimer's disease, Friedreich's ataxia (FRDA), multiple …