Teleost muscle first arises in early embryonic life and its development is driven by molecules
present in the egg yolk and modulated by environmental stimuli including temperature and …

▪ Abstract Embryological and genetic studies of mouse, bird, zebrafish, and frog embryos are
providing new insights into the regulatory functions of the myogenic regulatory factors …

The Spemann organizer in amphibian embryos is a tissue with potent head-inducing activity,
the molecular nature of which is unresolved. Here we describe dickkopf-1 (dkk-1), which …

The maturation of single-cell transcriptomic technologies has facilitated the generation of
comprehensive cellular atlases from whole embryos,,–. A majority of these data, however …

Hedgehog pathway components and select G protein-coupled receptors (GPCRs) localize
to the primary cilium, an organelle specialized for signal transduction. We investigated …

Each skeletal muscle acquires its unique size before birth, when terminally differentiating
myocytes fuse to form a defined number of multinucleated myofibres. Although mice in which …

We demonstrate that the tendons associated with the axial skeleton derive from a heretofore
unappreciated, fourth compartment of the somites. Scleraxis (Scx), a bHLH transcription …

The notochord is the defining structure of the chordates, and has essential roles in
vertebrate development. It serves as a source of midline signals that pattern surrounding …

Growth in fish involves the recruitment and hypertrophy of muscle fibres. Muscle recruitment
is particularly important in species that reach a large ultimate body size. The number of …

We describe the isolation of zebrafish Fgf8 and its expression during gastrulation,
somitogenesis, fin bud and early brain development. By demonstrating genetic linkage and …