Clinically ineffective reperfusion after endovascular therapy in acute ischemic stroke

X Nie, X Leng, Z Miao, M Fisher, L Liu - Stroke, 2023‏ - ahajournals.org
Endovascular treatment is a highly effective therapy for acute ischemic stroke due to large
vessel occlusion. However, in clinical practice, nearly half of the patients do not have …

No-reflow phenomenon in stroke patients: a systematic literature review and meta-analysis of clinical data

A Mujanovic, F Ng, TR Meinel… - … Journal of Stroke, 2024‏ - journals.sagepub.com
Background: The no-reflow phenomenon refers to the absence of microvascular reperfusion
despite macrovascular reperfusion. Aim: The aim of this analysis was to summarize the …

Effect of intra-arterial alteplase vs placebo following successful thrombectomy on functional outcomes in patients with large vessel occlusion acute ischemic stroke: the …

A Renú, M Millán, L San Román, J Blasco… - Jama, 2022‏ - jamanetwork.com
Importance It is estimated that only 27% of patients with acute ischemic stroke and large
vessel occlusion who undergo successful reperfusion after mechanical thrombectomy are …

Prevalence and significance of impaired microvascular tissue reperfusion despite macrovascular angiographic reperfusion (no-reflow)

FC Ng, L Churilov, N Yassi, TJ Kleinig, V Thijs, T Wu… - Neurology, 2022‏ - neurology.org
Background and Objectives The relevance of impaired microvascular tissue-level
reperfusion despite complete upstream macrovascular angiographic reperfusion (no-reflow) …

No-reflow post-recanalization in acute ischemic stroke: mechanisms, measurements, and molecular markers

CP Sperring, WM Savage, MG Argenziano, VP Leifer… - Stroke, 2023‏ - ahajournals.org
Acute ischemic stroke remains the primary cause of disability worldwide. For patients with
large vessel occlusions, intravenous thrombolysis followed by mechanical thrombectomy …

Risk factors, pathophysiologic mechanisms, and potential treatment strategies of futile recanalization after endovascular therapy in acute ischemic stroke

G Deng, Y Chu, J **ao, K Shang, LQ Zhou… - Aging and …, 2023‏ - pmc.ncbi.nlm.nih.gov
Endovascular therapy is the first-line treatment for acute ischemic stroke. However, studies
have shown that, even with the timely opening of occluded blood vessels, nearly half of all …

“No-reflow” phenomenon in acute ischemic stroke

Y Zhang, M Jiang, Y Gao, W Zhao… - Journal of Cerebral …, 2024‏ - journals.sagepub.com
Acute ischemic stroke (AIS) afflicts millions of individuals worldwide. Despite the
advancements in thrombolysis and thrombectomy facilitating proximal large artery …

Microvascular dysfunction in blood-brain barrier disruption and hypoperfusion within the infarct posttreatment are associated with cerebral edema

FC Ng, L Churilov, N Yassi, TJ Kleinig, V Thijs, TY Wu… - Stroke, 2022‏ - ahajournals.org
Background: Factors contributing to cerebral edema in the post-hyperacute period of
ischemic stroke (first 24–72 hours) are poorly understood. Blood-brain barrier (BBB) …

No-reflow phenomenon following stroke recanalization therapy: clinical assessment advances: a narrative review

Y Kan, S Li, B Zhang, Y Ding, W Zhao, X Ji - Brain Circulation, 2023‏ - journals.lww.com
The no-reflow phenomenon (NRP) after successful vascular recanalization in acute
ischemic stroke (AIS) has become a major cause of poor clinical prognosis and ineffective …

No-reflow after recanalization in ischemic stroke: From pathomechanisms to therapeutic strategies

F Sun, J Zhou, X Chen, T Yang… - Journal of Cerebral …, 2024‏ - journals.sagepub.com
Endovascular reperfusion therapy is the primary strategy for acute ischemic stroke. No-
reflow is a common phenomenon, which is defined as the failure of microcirculatory …